Huenges Katharina, Pokorny Saskia, Berndt Rouven, Cremer Jochen, Lutter Georg
Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Ultrasound Med Biol. 2017 May;43(5):974-980. doi: 10.1016/j.ultrasmedbio.2016.12.011. Epub 2017 Feb 16.
The porcine model is a commonly used animal model in cardiovascular research. Along with new innovative operative techniques, choice of the optimal imaging technique is crucial. Transesophageal echocardiography (TEE) is a reliable imaging tool is highly important in a large number of experimental evaluations. But so far, TEE data for swine are limited, and few standard values have been established for the porcine model. The experience and baseline results for TEE in 45 swine are presented in this study. A full TEE examination was conducted in 45 German landrace or German large white swine, with an average body weight of 49 ± 3 kg, before experimental off-pump mitral valved stent implantation. Additionally hemodynamic measurements were evaluated. The valve implantation procedure was guided solely by real-time 3-D TEE. Baseline values of standard echocardiographic parameters are provided and, where appropriate, compared with human reference values. TEE proved to be an adequate imaging technique in this experimental porcine animal model. The baseline TEE and hemodynamic parameters established for the widely used porcine model can serve as a reference in future studies.
猪模型是心血管研究中常用的动物模型。随着新的创新手术技术的出现，选择最佳成像技术至关重要。经食管超声心动图（TEE）是一种可靠的成像工具，在大量实验评估中非常重要。但到目前为止，猪的TEE数据有限，且针对猪模型几乎没有建立标准值。本研究展示了45头猪的TEE经验和基线结果。在45头德国长白猪或德国大白猪（平均体重49±3 kg）进行非体外循环二尖瓣带瓣支架植入实验前，进行了全面的TEE检查。此外，还评估了血流动力学测量值。瓣膜植入手术仅由实时三维TEE引导。提供了标准超声心动图参数的基线值，并在适当情况下与人类参考值进行比较。在这个实验性猪动物模型中，TEE被证明是一种合适的成像技术。为广泛使用的猪模型建立的基线TEE和血流动力学参数可为未来研究提供参考。
