Katle E J, Hatlebakk J G, Grimstad T, Kvaløy J T, Steinsvåg S K
Department of Otolaryngology, Head and Neck Surgery, Stavanger University Hospital, Stavanger, Norway.
Department of Medicine, Haukeland University Hospital, Norway.
Rhinology. 2017 Mar 1;55(1):27-33. doi: 10.4193/Rhino16.275.
The pathophysiology of chronic rhinosinusitis (CRS) is unclear. It has been discussed for decades whether gastro-oesophageal reflux (GOR) may be a contributing factor for some patients. The aim of the present study was to evaluate the level of GOR in an unselected group of patients with CRS using multichannel impedance-pH monitoring.
Consecutive patients with CRS diagnosed using the EPOS2012 criteria, completed questionnaires on GOR symptoms and were offered 24-h multichannel intraluminal impedance (MII)-pH monitoring. The results were compared with a group of healthy controls.
Forty-six patients completed MII-pH-monitoring and were compared with 45 control subjects, with comparable age and gender distributions. The median number of reflux episodes in the patients was 56.5 compared with 33 in controls, while, the numbers of proximal reflux episodes was 27.5 versus 3, respectively. Thirty nine patients had abnormal pH-impedance recordings compared with five controls.
The CRS patients had significantly higher incidences of gastro-oesophageal reflux compared with asymptomatic controls. The results of this study suggest that GOR may be a causative or contributing factor of CRS.
慢性鼻-鼻窦炎（CRS）的病理生理学尚不清楚。几十年来一直在讨论胃食管反流（GOR）是否可能是部分患者的一个促成因素。本研究的目的是使用多通道阻抗-pH监测评估一组未经挑选的CRS患者的GOR水平。
连续纳入符合EPOS2012标准诊断的CRS患者，完成关于GOR症状的问卷调查，并接受24小时多通道腔内阻抗（MII）-pH监测。将结果与一组健康对照进行比较。
46例患者完成了MII-pH监测，并与45名对照受试者进行比较，两组年龄和性别分布相当。患者反流发作的中位数为56.5次，而对照组为33次，近端反流发作次数分别为27.5次和3次。39例患者的pH-阻抗记录异常，而对照组为5例。
与无症状对照相比，CRS患者胃食管反流的发生率显著更高。本研究结果表明，GOR可能是CRS的一个致病或促成因素。
