Salminen Tiina S, Oliveira Marcos T, Cannino Giuseppe, Lillsunde Päivi, Jacobs Howard T, Kaguni Laurie S
Institute of Biosciences and Medical Technology, FI-331014, University of Tampere, Finland.
Institute of Biosciences and Medical Technology, FI-331014, University of Tampere, Finland; Department of Biochemistry and Molecular Biology, Center for Mitochondrial Science and Medicine, Michigan State University, East Lansing, MI 48824, USA; Departamento de Tecnologia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista "Júlio de Mesquita Filho", Jaboticabal, SP 14884-900, Brazil.
Mitochondrion. 2017 May;34:75-83. doi: 10.1016/j.mito.2017.02.001. Epub 2017 Feb 16.
We evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and non-coding A+T region variation on mtDNA copy number, and demonstrate that copy number correlates with mitochondrial biochemistry and metabolically important traits such as development time. For example, high mtDNA copy number correlates with longer development times. Our findings support the hypothesis that mtDNA copy number is modulated by mtDNA genome variation and suggest that it affects OXPHOS efficiency through changes in the organization of the respiratory membrane complexes to influence organismal phenotype.
我们评估了自然线粒体DNA（mtDNA）变异对果蝇胞质杂种菌株中mtDNA拷贝数、生化特征和生活史特征的作用。我们证明了编码区和非编码A+T区变异对mtDNA拷贝数的影响，并证明拷贝数与线粒体生物化学以及发育时间等代谢重要性状相关。例如，高mtDNA拷贝数与较长的发育时间相关。我们的研究结果支持了mtDNA拷贝数受mtDNA基因组变异调节的假说，并表明它通过呼吸膜复合物组织的变化影响氧化磷酸化效率，从而影响生物体表型。
