Gokhale M, Gupta D, Gupta U, Faraz R, Sandhu S S
Department of Biotechnology, St. Aloysius College (Autonomous), Jabalpur-482001, MP. India.
Biodesign Innovation Centre, St. Aloysius College (Autonomous), Jabalpur, M.P-482001. India.
Recent Pat Biotechnol. 2017;11(2):120-140. doi: 10.2174/1872208311666170215151834.
Endophytic fungi are taxonomically and ecologically heterogeneous group of organisms, mainly belonging to the Ascomycotina and Deuteromycotina. Endophytes usually produce the enzymes necessary for the colonization of plant tissues. Endophytes are able to utilize components of plant cells without disturbing host metabolism, which is confirmed by isozyme analysis and studies on substrate utilization. The patents related to enzymes and metabolites produced by endophytic fungi are associated with their ecological significance. Application of metabolites and growth promoting factors produced from endophytic fungi, in the pharmaceutical and agricultural industries, is now well established. The patents on secretion of extracellular enzymes in vitro by endophytic fungi needed for cell wall degradation, support the hypothesis that fungal endophytes represent a group of organisms specialized to live within plant tissue.
This review presents the patents granted on different aspects of endophytic fungi for the last 11 years. This expresses the scenario and impact of these patents regarding significance in human society.
In the last few years, research and inventions regarding the different aspects of endophytic fungi beneficial for host plant as well as for human beings have been carried out, which is supported by the increasing number of patents granted on endophytic fungi.
内生真菌是一类在分类学和生态学上具有异质性的生物群体,主要属于子囊菌亚门和半知菌亚门。内生菌通常产生定殖于植物组织所需的酶。内生菌能够利用植物细胞的成分而不干扰宿主代谢,这一点已通过同工酶分析和底物利用研究得到证实。与内生真菌产生的酶和代谢产物相关的专利涉及其生态意义。内生真菌产生的代谢产物和生长促进因子在制药和农业产业中的应用现已得到充分确立。关于内生真菌在体外分泌用于细胞壁降解的胞外酶的专利,支持了真菌内生菌是一类专门生活在植物组织内的生物群体这一假说。
本综述介绍了过去11年中在内生真菌不同方面授予的专利。这展现了这些专利在人类社会中的重要意义、情况及影响。
在过去几年中,已经开展了关于内生真菌对宿主植物和人类有益的不同方面的研究和发明,这一点从授予内生真菌的专利数量不断增加得到了佐证。