Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Via Taramelli 12, 27100, Pavia, Italy.
Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
Curr Pharm Des. 2017;23(17):2474-2487. doi: 10.2174/1381612823666170215145855.
Tea and coffee are the second and third most consumed beverages after water, respectively. The high consumption of these beverages is due to the sensorial properties and effects on psychological and physiological functions, induced by caffeine and many other bioactive components responsible for the protective effects on human health generally ascribed to these beverages.
The goal of this review article is to collect the scientific data obtained from clinical trials published in the last five years on the role of tea and coffee consumption against cardiovascular diseases (CVDs) and CVD risk factors such as hypertension, hyperglicemia, and hyperlipidaemia.
In normal weight subjects, clinical trials showed that the consumption of tea is inversely associated to CVD risk factors or no association was found. Differently, in overweight subjects, the clinical trials and the metaanalyses showed an inverse correlation between tea consumption and CVDs. As regards coffee, it has long been suspected to be associated to high risk of CVDs. Nevertheless, some recent investigations reported that moderate coffee consumption have no effect or even protective effects against CVDs risk factors. The results of the metaanalyses confirm this trend suggesting that moderate coffee drinkers could be associated to a lower risk of CVDs than non- or occasional coffee drinkers or no association can be demonstrated between coffee consumption and CVDs.
Literature data on tea consumption and CVD risk factors support that tea consumption reduces some risk factors especially in overweight people and obese subjects. Therefore, these results seem to suggest that tea could exert a protective effects against CVD development. As regards coffee, the results are controversial and did not allow to draw conclusions. Therefore, further research is needed before definitive recommendations for coffee consumption against CVD development can be made.
茶和咖啡分别是继水之后消费第二和第三高的饮品。这些饮品的高消费归因于其感官特性以及咖啡因和许多其他生物活性成分对心理和生理功能的影响,这些成分通常被认为对人体健康具有保护作用。
本文旨在收集过去五年发表的临床试验中关于茶和咖啡消费对心血管疾病(CVD)以及高血压、高血糖和高血脂等 CVD 风险因素的作用的科学数据。
在正常体重的受试者中,临床试验表明茶的消费与 CVD 风险因素呈负相关或没有关联。相反,在超重受试者中,临床试验和荟萃分析表明茶的消费与 CVD 之间存在反比关系。至于咖啡,人们长期以来一直怀疑它与 CVD 风险高有关。然而,一些最近的研究报告称,适量饮用咖啡对 CVD 风险因素没有影响,甚至具有保护作用。荟萃分析的结果证实了这一趋势,表明适量饮用咖啡的人患 CVD 的风险可能低于不饮用或偶尔饮用咖啡的人,或者饮用咖啡与 CVD 之间没有关联。
关于茶消费与 CVD 风险因素的文献数据支持茶消费可降低某些风险因素,尤其是在超重和肥胖人群中。因此,这些结果似乎表明茶可能对 CVD 的发展具有保护作用。至于咖啡,结果存在争议,无法得出结论。因此,在对咖啡消费预防 CVD 发展做出明确建议之前,还需要进一步的研究。