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在以色列CORDIS研究中对自由生活的受试者进行的血清脂蛋白及与健康相关习惯与咖啡和茶消费的关联研究。

Association of serum lipoproteins and health-related habits with coffee and tea consumption in free-living subjects examined in the Israeli CORDIS Study.

作者信息

Green M S, Harari G

机构信息

Cardiovascular Epidemiology Unit, Occupational Health and Rehabilitation Institute, Raanana, Israel.

出版信息

Prev Med. 1992 Jul;21(4):532-45. doi: 10.1016/0091-7435(92)90061-l.

DOI:10.1016/0091-7435(92)90061-l
PMID:1409495
Abstract

BACKGROUND

A positive association between coffee consumption and serum cholesterol levels has been demonstrated and recent results indicate that this may be due to a lipid-rich fraction present mainly in boiled coffee. The possible effects of tea consumption are less clear, although evidence has been presented which suggests that tea drinkers have lower cholesterol levels. The associations between serum lipids and lipoproteins and coffee and tea consumption were examined in the Israel CORDIS study.

METHODS

Employees of 21 factories were screened for cardiovascular disease risk factors between 1985 and 1987. Detailed data on coffee and tea consumption and serum lipids and lipoproteins were available for 3,858 men and 1,511 women.

RESULTS AND CONCLUSIONS

Consumption of five or more cups of coffee per day was reported by 10.1% of men and 8.7% of women, whereas only 3.4% of men and 2.2% of women consumed similar quantities of tea. After controlling for a number of potential confounders, coffee consumption (particularly "mud" coffee) was strongly and positively associated with higher serum total and low-density lipoprotein cholesterol levels in both sexes (consumers of five or more cups per day had cholesterol levels up to 18 mg/dl higher than abstainers) and with high-density lipoprotein cholesterol in women. There was a nonsignificant negative association between tea consumption and serum cholesterol (cholesterol levels about 5 mg/dl more in abstainers than in those consuming five or more cups per day). In general, more negative health-related habits were reported with increased coffee consumption, whereas this relationship was not found for tea drinking. The relatively small percentage of heavy tea drinkers limits the conclusions that one can draw from this study and controlled trials are needed to evaluate possible lipid-lowering effects of tea consumption.

摘要

背景

咖啡消费与血清胆固醇水平之间已证实存在正相关,近期结果表明这可能归因于主要存在于煮咖啡中的富含脂质的部分。尽管已有证据表明饮茶者胆固醇水平较低,但饮茶的可能影响尚不太明确。以色列CORDIS研究对血清脂质和脂蛋白与咖啡及茶消费之间的关联进行了研究。

方法

1985年至1987年间,对21家工厂的员工进行了心血管疾病风险因素筛查。有3858名男性和1511名女性提供了关于咖啡和茶消费以及血清脂质和脂蛋白的详细数据。

结果与结论

10.1%的男性和8.7%的女性报告每天饮用五杯或更多咖啡,而只有3.4%的男性和2.2%的女性饮用等量的茶。在控制了一些潜在混杂因素后,咖啡消费(尤其是“泥”咖啡)与男女血清总胆固醇和低密度脂蛋白胆固醇水平升高呈强烈正相关(每天饮用五杯或更多咖啡的消费者胆固醇水平比不饮用者高出18毫克/分升),且与女性高密度脂蛋白胆固醇呈正相关。饮茶与血清胆固醇之间存在不显著的负相关(不饮茶者的胆固醇水平比每天饮用五杯或更多茶者高约5毫克/分升)。总体而言,随着咖啡消费量增加,报告的与健康相关的不良习惯更多,而饮茶未发现这种关系。重度饮茶者的比例相对较小,限制了本研究得出的结论,需要进行对照试验来评估饮茶可能的降脂作用。

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