Laboratory of Experimental Endocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg 199034. Russian Federation.
Curr Pharm Des. 2017;23(27):3923-3927. doi: 10.2174/1381612823666170215145125.
Stress plays a leading role in maintaining the physical health of the body. Various health effects of preconditioning mild stress strongly confirm this statement. Preconditioning mild stress, which is everyday event of animal and human life, may attenuate the development and aggravation of diseases including such widespread pathology as gastric ulceration. Preconditioning mild stress may diminish gastric injury formation caused by severe stress. Gastroprotective influence of preconditioning mild stress is known to be mediated by prostaglandins. In the present article, we focus on the data suggesting that glucocorticoids released in response to preconditioning mild stressor are important players of gastroprotective influence of preconditioning stress.
压力在维持身体健康方面起着主导作用。轻度预处理应激对各种健康的影响有力地证实了这一说法。轻度预处理应激是动物和人类生活中的日常事件，它可能减轻包括胃溃疡等广泛病理在内的疾病的发展和恶化。轻度预处理应激可以减少严重应激引起的胃损伤形成。已知轻度预处理应激的胃保护作用是通过前列腺素介导的。在本文中，我们重点关注的数据表明，预处理轻度应激源释放的糖皮质激素是预处理应激胃保护作用的重要参与者。
