Mitchell M D, Grzyboski C F
Department of Reproductive Medicine, University of California, San Diego, La Jolla 92093.
Prostaglandins Leukot Med. 1987 Aug;28(3):303-12. doi: 10.1016/0262-1746(87)90119-3.
Intrauterine tissues from women at term of pregnancy metabolized arachidonic acid by way of lipoxygenase pathways that included 5-, 12-, and 15- lipoxygenases. The major lipoxygenase product formed by amnion obtained before labor was leukotriene B4 and after labor was 12- hydroxyeicosatetraenoic acid (12-HETE). Chorion laeve and decidua vera synthesized predominantly 15-HETE at all times and placenta produced mainly 12-HETE. Trends existed for increased prostaglandin formation with labor by amnion, chorion laeve and decidua vera and for increased lipoxygenase product formation by chorion laeve, decidua vera and placenta. It is suggested that products of arachidonic acid metabolism by way of lipoxygenase and cyclooxygenase pathways play significant roles in the control of fetal and uteroplacental hemodynamics and the mechanism(s) of parturition.
足月妊娠女性的子宫内组织通过包括5-、12-和15-脂氧合酶的脂氧合酶途径代谢花生四烯酸。分娩前获得的羊膜产生的主要脂氧合酶产物是白三烯B4，分娩后是12-羟基二十碳四烯酸（12-HETE）。平滑绒毛膜和真蜕膜在所有时间主要合成15-HETE，胎盘主要产生12-HETE。羊膜、平滑绒毛膜和真蜕膜在分娩时前列腺素形成增加，平滑绒毛膜、真蜕膜和胎盘的脂氧合酶产物形成增加，存在这样的趋势。提示花生四烯酸通过脂氧合酶和环氧化酶途径代谢的产物在控制胎儿和子宫胎盘血流动力学及分娩机制中起重要作用。
