Bennett P R, Elder M G, Myatt L
Institute of Obstetrics and Gynaecology, Hammersmith Hospital, London, England.
Prostaglandins. 1987 Jun;33(6):837-44. doi: 10.1016/0090-6980(87)90112-2.
The effects of the lipoxygenase products of arachidonic acid, 5- and 12-hydroxyeicosatetraenoic acid (5- and 12-HETE) and leukotriene B4 (LTB4), on the spontaneous contractility of lower uterine segment human myometrial strips obtained prior to labour have been studied in vitro. 5-HETE gave a dose- dependent (10-500ng) increase in both the rate of contractions and overall contractility of myometrial strips while 12-HETE and LTB4 had no effect at the same concentrations. Prostaglandin F2 alpha (50ng) contracted all myometrial strips in a similar pattern to 5-HETE but was approximately 10 times more potent. The effect of 5-HETE may be direct or perhaps indirect via interaction with the cyclo-oxygenase pathway. The findings do not disprove the contention that the onset of parturition may be characterised by a switch in arachidonic acid metabolism in intra-uterine tissues from lipoxygenase to cyclo-oxygenase products.
已在体外研究了花生四烯酸的脂氧合酶产物5-羟基二十碳四烯酸（5-HETE）、12-羟基二十碳四烯酸（12-HETE）和白三烯B4（LTB4）对分娩前获取的人子宫下段肌层条自发收缩性的影响。5-HETE使肌层条的收缩速率和整体收缩性呈剂量依赖性（10 - 500ng）增加，而12-HETE和LTB4在相同浓度下无作用。前列腺素F2α（50ng）使所有肌层条收缩，其模式与5-HETE相似，但效力约强10倍。5-HETE的作用可能是直接的，也可能是通过与环氧化酶途径相互作用间接产生的。这些发现并未反驳分娩开始可能以子宫内组织中花生四烯酸代谢从脂氧合酶产物向环氧化酶产物转变为特征这一论点。
