克罗恩病与帕金森病的并发情况。
Occurrence of Crohn's disease with Parkinson's disease.
作者信息
Fujioka Shinsuke, Curry Sadie E, Kennelly Kathleen D, Tacik Pawel, Heckman Michael G, Tsuboi Yoshio, Strongosky Audrey J, van Gerpen Jay A, Uitti Ryan J, Ross Owen A, Ikezu Tsuneya, Wszolek Zbigniew K
机构信息
Department of Neurology, Mayo Clinic, Jacksonville, FL, United States; Department of Neurology, Fukuoka University, Fukuoka 8140180, Japan.
Department of Neurology, Mayo Clinic, Jacksonville, FL, United States; Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn Medical Center, Sigmund-Freund-Str. 25, 53127 Bonn, Germany.
出版信息
Parkinsonism Relat Disord. 2017 Apr;37:116-117. doi: 10.1016/j.parkreldis.2017.01.013. Epub 2017 Feb 10.
Abstract
We retrospectively investigated the co-occurrence of Crohn's disease in a cohort of 876 patients with Parkinson's disease, based on the observation that LRRK2 is a shared genetic risk factor. We identified 2 patients with Crohn's disease; this number was consistent with the number of cases expected in the general population.
摘要
基于LRRK2是一个共同遗传风险因素这一观察结果，我们对876例帕金森病患者队列中克罗恩病的共现情况进行了回顾性研究。我们识别出2例克罗恩病患者；这一数字与普通人群中预期的病例数一致。
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本文引用的文献
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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.全基因组荟萃分析将确认的克罗恩病易感性位点数量增加到 71 个。
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The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease.富含亮氨酸重复激酶 2（LRRK2）在帕金森病中的作用。
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The genetics of Crohn's disease.克罗恩病的遗传学
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Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia.亮氨酸丰富重复激酶2基因（Lrrk2）G2385R突变是亚洲帕金森病的一个祖传风险因素。
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The epidemiology and natural history of Crohn's disease in population-based patient cohorts from North America: a systematic review.北美基于人群的患者队列中克罗恩病的流行病学和自然史：一项系统综述。
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