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青少年精索静脉曲张患者的顺行硬化疗法

Antegrade sclerotherapy in adolescent varicocele patients.

作者信息

Keene D J B, Cervellione R M

机构信息

Department of Paediatric Urology, Royal Manchester Children's Hospital, Oxford Road, Manchester, UK.

Department of Paediatric Urology, Royal Manchester Children's Hospital, Oxford Road, Manchester, UK.

出版信息

J Pediatr Urol. 2017 Jun;13(3):305.e1-305.e6. doi: 10.1016/j.jpurol.2016.12.018. Epub 2017 Jan 29.

DOI:10.1016/j.jpurol.2016.12.018
PMID:28215837
Abstract

INTRODUCTION

In the 1970s, Tauber described the antegrade sclerotherapy technique to treat varicoceles, and reported a 10% recurrence rate. The present study aimed to evaluate paediatric success rates and the effect of modifications to the surgical technique.

METHODS

A prospective study was performed of all adolescent patients undergoing antegrade sclerotherapy surgery. Each patient had an idiopathic varicocele with spontaneous venous reflux on Doppler examination, and underwent cannulation of a pampiniform plexus vein via a scrotal incision under general anaesthetic. Aethoxysklerol 3% (2 ml/kg) maximum 3 ml was injected into the pampiniform plexus vein under fluoroscopic monitoring. Success was assessed by clinical examination and Doppler ultrasound 3, 6 and 9 months after surgery. Data were presented as median (interquartile range). Patients were split into three groups: Group A - liquid sclerotherapy with Y connector; Group B - liquid sclerotherapy direct to cannula; and Group C - foam sclerotherapy direct to cannula. Fisher's exact test was used to compare the success rates in each group.

RESULTS

A total of 91 patients underwent antegrade sclerotherapy. The median age was 14.8 years (range 13.7-15.5). Eleven persistent varicoceles occurred and were diagnosed by Doppler ultrasound. The success rate of surgery was 58% in Group A, 90% in Group B and 96% in Group C. Success was significantly higher in Group B and Group C compared with Group A. No testicular atrophy occurred; two wound infections, two haematomas and one hydrocele were recorded (Table).

CONCLUSION

Introduction of antegrade sclerotherapy in the adolescent population resulted in a safe and cost-effective method for the management of adolescent varicocele. Several modifications to the technique have been introduced to achieve a high success rate (96%) with minimal complications.

摘要

引言

20世纪70年代,陶伯描述了顺行硬化疗法治疗精索静脉曲张的技术,并报告复发率为10%。本研究旨在评估儿科患者的成功率以及手术技术改良的效果。

方法

对所有接受顺行硬化疗法手术的青少年患者进行前瞻性研究。每位患者均患有特发性精索静脉曲张,多普勒检查显示有自发性静脉反流,在全身麻醉下经阴囊切口对蔓状静脉丛静脉进行插管。在透视监测下,将3%的聚多卡醇(最大3毫升,2毫升/千克)注入蔓状静脉丛静脉。术后3、6和9个月通过临床检查和多普勒超声评估手术效果。数据以中位数(四分位间距)表示。患者分为三组:A组——使用Y形连接器进行液体硬化疗法;B组——直接向插管进行液体硬化疗法;C组——直接向插管进行泡沫硬化疗法。采用Fisher精确检验比较每组的成功率。

结果

共有91例患者接受了顺行硬化疗法。中位年龄为14.8岁(范围13.7 - 15.5岁)。出现了11例持续性精索静脉曲张,通过多普勒超声诊断。A组手术成功率为58%,B组为90%,C组为96%。B组和C组的成功率显著高于A组。未发生睾丸萎缩;记录到2例伤口感染、2例血肿和1例鞘膜积液(表)。

结论

在青少年人群中引入顺行硬化疗法为青少年精索静脉曲张的治疗提供了一种安全且经济有效的方法。对该技术进行了多项改良,以实现高成功率(96%)且并发症最少。

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