Poukkula A, Hakala M, Huhti E
Department of Medicine, University Central Hospital, Oulu, Finland.
Respiration. 1987;51(4):272-6. doi: 10.1159/000195213.
Serum copper (SCu), zinc (SZn) and ceruloplasmin (SCP) concentrations were measured in 199 patients with lung cancer and 81 with nonmalignant lung disease. No significant differences were detected between these groups in the mean concentrations or in the SCu:SZn ratio, nor was any correlation found between the histological type or clinical extent of the tumor and the level of SCu, SZn or SCP. SCu and SCP increased significantly in accordance with the symptomatic stages of Feinstein, and in a parallel manner. These measures were also significantly higher in the patients who died within 4 months of diagnosis than in those who lived for 4 months or longer. SZn was similar throughout and was not predictive of the prognosis. It is concluded that SCu, SZn and SCP determinations are of no help in distinguishing malignant from nonmalignant lung disease and are only of limited importance for estimating the extent of the disease or the prognosis of a patient with lung cancer.
对199例肺癌患者和81例非恶性肺部疾病患者的血清铜（SCu）、锌（SZn）和铜蓝蛋白（SCP）浓度进行了测量。这些组之间在平均浓度或SCu:SZn比值方面未检测到显著差异，肿瘤的组织学类型或临床范围与SCu、SZn或SCP水平之间也未发现任何相关性。SCu和SCP根据Feinstein症状分期显著增加，且呈平行关系。在诊断后4个月内死亡的患者中，这些指标也显著高于存活4个月或更长时间的患者。SZn在整个过程中相似，不能预测预后。结论是，SCu、SZn和SCP测定无助于区分恶性与非恶性肺部疾病，对于评估疾病程度或肺癌患者的预后仅具有有限的重要性。
