Yoshida D, Ikeda Y, Nakazawa S
Nippon Medical School, Department of Neurosurgery, Tokyo, Japan.
J Neurooncol. 1993 May;16(2):109-15. doi: 10.1007/BF01324697.
Serum copper and zinc concentrations and copper/zinc ratios have been shown to be increased in several types of human malignancies, including human brain tumors. In this study, copper and zinc levels and copper/zinc ratios were determined by atomic absorption analysis in tissue and serum from 29 primary and metastatic brain tumor patients. Metastatic carcinomas and malignant gliomas revealed significantly higher tissue copper concentrations than control tissues and meningiomas. Malignant gliomas demonstrated significantly higher tissue copper/zinc ratios. Both serum copper and copper/zinc ratio were significantly higher in the metastatic carcinoma group than control; however, serum copper levels in malignant glioma patients were not significantly different from control tissues. There were no differences both in the serum and the tissue concentrations of these trace elements in meningiomas and controls. These data suggested that copper, an important angiogenic factors, is accumulated within the malignant tissues of metastatic carcinoma and malignant glioma, but not meningiomas. These findings may have implications regarding angiogenesis in these tumors.
血清铜和锌浓度以及铜/锌比值已被证明在包括人脑肿瘤在内的几种人类恶性肿瘤中会升高。在本研究中，通过原子吸收分析法测定了29例原发性和转移性脑肿瘤患者的组织和血清中的铜、锌水平以及铜/锌比值。转移性癌和恶性胶质瘤的组织铜浓度显著高于对照组织和脑膜瘤。恶性胶质瘤的组织铜/锌比值显著更高。转移性癌组的血清铜和铜/锌比值均显著高于对照组；然而，恶性胶质瘤患者的血清铜水平与对照组织无显著差异。脑膜瘤和对照组的这些微量元素的血清和组织浓度均无差异。这些数据表明，铜作为一种重要的血管生成因子，在转移性癌和恶性胶质瘤的恶性组织中积聚，但在脑膜瘤中不积聚。这些发现可能对这些肿瘤中的血管生成有影响。
