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青少年中的维生素D:当前的建议足够吗?

Vitamin D in adolescents: Are current recommendations enough?

作者信息

Smith Taryn J, Lanham-New Susan A, Hart Kathryn H

机构信息

Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.

Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.

出版信息

J Steroid Biochem Mol Biol. 2017 Oct;173:265-272. doi: 10.1016/j.jsbmb.2017.02.010. Epub 2017 Feb 16.

Abstract

Vitamin D is essential for bone development during adolescence and low vitamin D status during this critical period of growth may impact bone mineralization, potentially reducing peak bone mass and consequently increasing the risk of osteoporosis in adulthood. Therefore, the high prevalence of vitamin D inadequacy and deficiency in adolescent populations is of great concern. However, there is currently a lack of consensus on the 25-hydroxyvitamin D [25(OH)D] concentration, the widely accepted biomarker of vitamin D status, that defines adequacy, and the vitamin D intake requirements to maintain various 25(OH)D thresholds are not well established. While the current intake recommendations of 10-15μg/day may be sufficient to prevent vitamin D deficiency (25(OH)D<25-30nmol/l), greater intakes may be needed to achieve the higher threshold levels proposed to represent adequacy (25(OH)D>50nmol/l). This review will address these concerns and consider if the current dietary recommendations for vitamin D in adolescents are sufficient.

摘要

维生素D对青少年骨骼发育至关重要,在这一关键生长时期维生素D水平较低可能会影响骨矿化,有可能降低峰值骨量,从而增加成年后患骨质疏松症的风险。因此,青少年人群中维生素D不足和缺乏的高患病率备受关注。然而,目前对于25-羟基维生素D[25(OH)D]浓度(维生素D状态广泛接受的生物标志物)如何定义充足性尚无共识,且维持各种25(OH)D阈值所需的维生素D摄入量也未明确确定。虽然目前10-15μg/天的摄入量建议可能足以预防维生素D缺乏(25(OH)D<25-30nmol/l),但可能需要更高的摄入量才能达到提议的代表充足性的更高阈值水平(25(OH)D>50nmol/l)。本综述将探讨这些问题,并考虑目前针对青少年维生素D的饮食建议是否足够。

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