性别影响老年人对急性有氧运动的血流介导的舒张反应。
Sex impacts the flow-mediated dilation response to acute aerobic exercise in older adults.
作者信息
Yoo Jeung-Ki, Pinto Michelle M, Kim Han-Kyul, Hwang Chueh-Lung, Lim Jisok, Handberg Eileen M, Christou Demetra D
机构信息
Department of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL, USA.
Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA.
出版信息
Exp Gerontol. 2017 May;91:57-63. doi: 10.1016/j.exger.2017.02.069. Epub 2017 Feb 16.
There is growing evidence of sex differences in the chronic effect of aerobic exercise on endothelial function (flow-mediated dilation; FMD) in older adults, but whether there are sex differences also in the acute effect of aerobic exercise on FMD in older adults is unknown. The purpose of this study was to test the hypothesis that sex modulates the FMD response to acute aerobic exercise in older adults. Thirteen older men and fifteen postmenopausal women (67±1 vs. 65±2years, means±SE, P=0.6), non-smokers, free of major clinical disease, participated in this randomized crossover study. Brachial artery FMD was measured: 1) prior to exercise; 2) 20min after a single bout of high-intensity interval training (HIIT; 40min; 4×4 intervals 90% peak heart rate (HRpeak)), moderate-intensity continuous training (MICT; 47min 70% HRpeak) and low-intensity continuous training (LICT; 47min 50% HRpeak) on treadmill; and 3) following 60-min recovery from exercise. In older men, FMD was attenuated by 45% following HIIT (5.95±0.85 vs. 3.27±0.52%, P=0.003) and by 37% following MICT (5.97±0.87 vs. 3.73±0.47%, P=0.03; P=0.9 for FMD response to HIIT vs. MICT) and was normalized following 60-min recovery (P=0.99). In postmenopausal women, FMD did not significantly change in response to HIIT (4.93±0.55 vs. 6.31±0.57%, P=0.14) and MICT (5.32±0.62 vs. 5.60±0.68%, P=0.99). In response to LICT, FMD did not change in postmenopausal women nor older men (5.21±0.64 vs. 6.02±0.73%, P=0.7 and 5.70±0.80 vs. 5.55±0.67%, P=0.99). In conclusion, sex and exercise intensity influence the FMD response to acute aerobic exercise in older adults.
越来越多的证据表明，有氧运动对老年人内皮功能（血流介导的血管舒张；FMD）的慢性影响存在性别差异，但有氧运动对老年人FMD的急性影响是否也存在性别差异尚不清楚。本研究的目的是检验性别是否调节老年人对急性有氧运动的FMD反应这一假设。13名老年男性和15名绝经后女性（67±1岁 vs. 65±2岁，均值±标准误，P = 0.6），非吸烟者，无重大临床疾病，参与了这项随机交叉研究。测量肱动脉FMD：1）运动前；2）在跑步机上进行单次高强度间歇训练（HIIT；40分钟；4×4个间歇，90%心率峰值（HRpeak））、中等强度持续训练（MICT；47分钟，70% HRpeak）和低强度持续训练（LICT；47分钟，50% HRpeak）后20分钟；3）运动后60分钟恢复后。在老年男性中，HIIT后FMD降低了45%（5.95±0.85% vs. 3.27±0.52%，P = 0.003），MICT后降低了37%（5.97±0.87% vs. 3.73±0.47%，P = 0.03；HIIT与MICT的FMD反应P = 0.9），60分钟恢复后恢复正常（P = 0.99）。在绝经后女性中，HIIT（4.93±0.55% vs. 6.31±0.57%，P = 0.14）和MICT（5.32±0.62% vs. 5.60±0.68%，P = 图99）后FMD无显著变化。对于LICT，绝经后女性和老年男性的FMD均无变化（5.21±0.64% vs. 6.02±0.73%，P = 0.7；5.70±0.80% vs. 5.55±0.67%，P = 0.99）。总之，性别和运动强度会影响老年人对急性有氧运动的FMD反应。
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