Kazennov A M, Maslova M N
Fiziol Zh Im I M Sechenova. 1993 Aug;79(8):66-72.
The enzyme activity in the cortex and medulla of the SHR was 1.5-2.0-fold lower than that of the WKY and Wistar rats. The Na, K-ATPase and Ca-ATPase activities were by 25 and 15% lower in the erythrocyte ghosts of the SHR than in normotensive rats. Removal of protein of the membrane skeleton from the erythrocyte membranes abolished the difference in the enzyme activity of normo- and hypertensive rats. The lower Na, K-ATPase activity in the SHR kidney seems to be an etiological factor in development of primary hypertension.
自发性高血压大鼠（SHR）皮质和髓质中的酶活性比正常血压的京都Wistar大鼠（WKY）和Wistar大鼠低1.5至2.0倍。SHR红细胞血影中的钠钾ATP酶和钙ATP酶活性比正常血压大鼠分别低25%和15%。从红细胞膜上去除膜骨架蛋白消除了正常血压和高血压大鼠之间的酶活性差异。SHR肾脏中较低的钠钾ATP酶活性似乎是原发性高血压发生的一个病因学因素。
