Yousafzai Ibrahim, Zahoor Abdul, Andrey Butrov, Ahmad Nauman
Department of Anesthesia, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Department of Anesthesiology and Reanimatology, Russian People's Friendship University, State Prize Laureate of USSR, Moscow, Russia.
Saudi J Anaesth. 2017 Jan-Mar;11(1):67-71. doi: 10.4103/1658-354X.197347.
To compare the outcomes such as postoperative nausea/vomiting, analgesic requirements, and hospital stay following the use of topical oxybuprocaine hydrochloride 0.4% or intravenous (IV) fentanyl in children undergoing strabismus surgery.
This was a prospective cohort study. Children operated under general anesthesia for strabismus were given topical oxybuprocaine hydrochloride 0.4% (Group T) and IV fentanyl (Group F) before surgery. The episodes of nausea/vomiting, pain score, requirement of additional analgesia during postoperative period, and duration of hospital stay were compared in two groups.
There were 47 children in Group T and 59 children in Group F. The median pain score in two groups were 2.38 (25% quartile; 2.0) and 3.00 (25% quartile; 3.00), respectively. The difference was significant (K W < 0.03). The episodes of nausea/vomiting in two groups were in 2 and 6 children in Group T and Group F, respectively. The median hospital stay of children of Group T and Group F were 242 and 285 min, respectively. The difference was not statistically significant ( = 0.22).
Using intraoperative topical oxybuprocaine drops, one can achieve better analgesic outcomes and reduce risk of nausea and vomiting compared to intravenous opioid analgesics and therefore, the hospital stay could also be marginally reduced.
比较在斜视手术儿童中使用0.4%盐酸奥布卡因局部用药或静脉注射芬太尼后，术后恶心/呕吐、镇痛需求和住院时间等结果。
这是一项前瞻性队列研究。接受斜视全身麻醉手术的儿童在手术前分别给予0.4%盐酸奥布卡因局部用药（T组）和静脉注射芬太尼（F组）。比较两组术后恶心/呕吐发作次数、疼痛评分、额外镇痛需求及住院时间。
T组有47名儿童，F组有59名儿童。两组的中位疼痛评分分别为2.38（四分位数间距；2.0）和3.00（四分位数间距；3.00）。差异有统计学意义（KW＜0.03）。T组和F组恶心/呕吐发作次数分别为2例和6例。T组和F组儿童的中位住院时间分别为242分钟和285分钟。差异无统计学意义（=0.22）。
与静脉注射阿片类镇痛药相比，术中使用局部盐酸奥布卡因滴眼液可获得更好的镇痛效果，降低恶心和呕吐风险，因此住院时间也可略有缩短。
