Martens Sean J, Geiger David K
Department of Chemistry, SUNY-College at Geneseo, Geneseo, New York 14454, USA.
Acta Crystallogr E Crystallogr Commun. 2017 Jan 13;73(Pt 2):162-167. doi: 10.1107/S2056989017000317. eCollection 2017 Feb 1.
Imidazole-containing compounds exhibit a myriad of pharmacological activities. Two tetra-chlorido-zincate salts of 4-carb-oxy-1-imidazol-3-ium, ImHCOH, are reported. Bis(4-carb-oxy-1-imidazol-3-ium) tetra-chlorido-zincate monohydrate, (CHNO)[ZnCl]·HO, (I), crystallizes as a monohydrate salt, while bis-(4-carb-oxy-1-imidazol-3-ium) tetra-chlorido-zincate bis-(1-imidazol-3-ium-4-carboxyl-ato) monohydrate, (CHNO)[ZnCl]·2CHNO·HO, (II), is a co-crystal salt with six residues: two ImHCOH cations, two formula units of the zwitterionic 1-imidazol-3-ium-4-carboxyl-ate, ImHCO, one tetra-chlorido-zincate anion and one water mol-ecule disordered over two sites in a 0.60 (4):0.40 (4) ratio. The geometric parameters of the ImHCOH and the ImHCO moieties are the same within the standard uncertainties of the measurements. Both compounds exhibit extensive hydrogen bonding, including involvement of the tetra-chlorido-zincate anion, resulting in inter-connected chains of anions joined by water mol-ecules.
含咪唑的化合物具有多种药理活性。本文报道了两种4-羧基-1-咪唑-3-鎓的四氯锌酸盐，即ImHCOH。双(4-羧基-1-咪唑-3-鎓)四氯锌酸盐水合物，(CHNO)[ZnCl]·HO，(I)，以水合物盐的形式结晶，而双(4-羧基-1-咪唑-3-鎓)四氯锌酸双(1-咪唑-3-鎓-4-羧基)水合物，(CHNO)[ZnCl]·2CHNO·HO，(II)，是一种含有六个残基的共晶盐：两个ImHCOH阳离子、两个两性离子1-咪唑-3-鎓-4-羧酸盐的化学式单元、一个四氯锌酸根阴离子和一个在两个位置上无序分布的水分子，比例为0.60 (4):0.40 (4)。在测量的标准不确定度范围内，ImHCOH和ImHCO部分的几何参数相同。两种化合物都表现出广泛的氢键作用，包括四氯锌酸根阴离子的参与，形成了由水分子连接的阴离子相互连接的链。
