Mizukami Y, Matsubara F, Hashimoto T, Terahata S, Noto H, Noguchi M, Michigishi T
Central Clinical Laboratory, Kanazawa University Hospital, Japan.
Acta Pathol Jpn. 1987 Jul;37(7):1157-64. doi: 10.1111/j.1440-1827.1987.tb00433.x.
A rare case of mucin-producing adenosquamous carcinoma of the thyroid gland is reported in a 57-year-old woman. Light microscopically, much of the tumor showed a feature of mucin-producing adenosquamous carcinoma; squamous cells and mucous signet ring cells. In the lower portion of the tumor, a calcified area containing small foci of follicular carcinoma and its squamous cell metaplasia was accompanied. Histochemically, neutral, non-sulphated and sulphated acid mucins were found in the mucous cells, and no thyroglobulin or calcitonin was detected in the tumor cells. Electron microscopically, some tonofibrils and mucin production were observed concomitantly in the tumor cells. These findings suggested the possibility that this mucin-producing adenosquamous carcinoma originated from squamous cell metaplasia of pre-existing follicular carcinoma.
本文报道了一例57岁女性甲状腺黏液生成型腺鳞癌的罕见病例。光学显微镜下，肿瘤大部分呈现黏液生成型腺鳞癌的特征，包括鳞状细胞和黏液印戒细胞。在肿瘤下部，伴有一个钙化区域，其中含有小灶性滤泡癌及其鳞状上皮化生。组织化学检查发现，黏液细胞中存在中性、非硫酸化和硫酸化酸性黏蛋白，肿瘤细胞中未检测到甲状腺球蛋白或降钙素。电子显微镜下，在肿瘤细胞中同时观察到一些张力原纤维和黏液生成。这些发现提示，这种黏液生成型腺鳞癌可能起源于既往滤泡癌的鳞状上皮化生。
