Farghadani Maryam, Soofi Ghazale Jamalipoor, Sarrami Amir Hossein
Department of Radiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2017 Jan 31;6:7. doi: 10.4103/2277-9175.199258. eCollection 2017.
To evaluate the correlation of magnetic resonance imaging (MRI) features of breast lesions of Breast Imaging Reporting and Database System (BI-RADS) category 4 with histopathologic results.
In a prospective study between December 2013 and April 2015, patients with suspicious mammographic and/or ultrasound findings referred for Breast MRI were evaluated. Patients with lesions of BI-RADS category 4 were enrolled with a written informed consent. In each patient, mass lesion (ML) or nonmass lesion (NML) was determined, and different characteristics of the lesions were recorded. A follow-up program was taken with mean 3-12 months. Patients who underwent core needle biopsy or open biopsy were summoned.
Seventy-eight females aged 24-67 years (mean 43.1 ± 8.8) met the inclusion criteria and had adequate samples for histopathologic study. Twenty-nine (37.2%) patients had ML and 49 (62.8%) patients had NML. Tissue sampling in 63 (80.7%) patients was through core needle biopsy and in 15 (19.2%) patients through surgery. A wide spectrum of benign and malignant pathologic diagnoses was seen. In statistical analysis, none of the MRI features has a significant correlation with any specific histopathologic diagnosis ( = 0.185). However, the relation between the MRI category (ML or NML) and pathology results was significant at level of 0.1 ( = 0.06).
This study showed that a wide spectrum of histopathologic results is seen in BI-RADS category 4. However, in this sample volume, none of the MRI features in this BI-RADS category has a significant correlation with any specific histopathologic diagnosis.
评估乳腺影像报告和数据系统（BI-RADS）4类乳腺病变的磁共振成像（MRI）特征与组织病理学结果的相关性。
在2013年12月至2015年4月的一项前瞻性研究中，对因乳腺钼靶和/或超声检查结果可疑而转诊进行乳腺MRI检查的患者进行评估。获得书面知情同意后，纳入BI-RADS 4类病变的患者。在每位患者中，确定肿块病变（ML）或非肿块病变（NML），并记录病变的不同特征。进行平均3至12个月的随访。召集接受粗针活检或开放活检的患者。
78名年龄在24至67岁（平均43.1±8.8岁）的女性符合纳入标准，并有足够的样本进行组织病理学研究。29名（37.2%）患者有ML，49名（62.8%）患者有NML。63名（80.7%）患者通过粗针活检进行组织取样，15名（19.2%）患者通过手术取样。观察到广泛的良性和恶性病理诊断。在统计分析中，没有任何MRI特征与任何特定的组织病理学诊断有显著相关性（P=0.185）。然而，MRI类别（ML或NML）与病理结果之间的关系在P=0.1水平上具有显著性（P=0.06）。
本研究表明，BI-RADS 4类病变有广泛的组织病理学结果。然而，在本样本量中，该BI-RADS类别的MRI特征与任何特定的组织病理学诊断均无显著相关性。
