Liu Dong-Dong, Mei Yan-Ai
School of Life Sciences, Fudan University, Shanghai 200433, China.
Sheng Li Xue Bao. 2017 Feb 25;69(1):109-121.
Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor beta superfamily. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting its potential value as a disease biomarker. It has been suggested that GDF-15 has neurotropic effects in the nervous system. Our studies showed that GDF-15 modulated the expression of neuronal K and Ca ion channels and increased the release of excitatory transmitter in the medial prefrontal cortex of mice. GDF-15 is also involved in the complex modulation of cancer and cardiovascular disease. Here, we reviewed studies involving the modulation of GDF-15 expression and its mechanisms, the primary pathological and physiological functions of GDF-15 in neurological and cardiovascular systems, and its role in cancer progression. The biological effects and the values of GDF-15 in basic research and clinical applications were also addressed.
生长分化因子-15（GDF-15）是转化生长因子β超家族的成员。在急性脑损伤、癌症、心血管疾病和炎症期间，GDF-15的表达会显著上调，这表明其作为疾病生物标志物的潜在价值。有人提出GDF-15在神经系统中具有神经营养作用。我们的研究表明，GDF-15调节小鼠内侧前额叶皮质中神经元钾离子和钙离子通道的表达，并增加兴奋性递质的释放。GDF-15还参与癌症和心血管疾病的复杂调节。在此，我们综述了涉及GDF-15表达调节及其机制、GDF-15在神经和心血管系统中的主要病理生理功能以及其在癌症进展中的作用的研究。还讨论了GDF-15在基础研究和临床应用中的生物学效应和价值。
