Carannante Novella, Rossi Marco, Fraganza Fiorentino, Coppola Grazia, Chiesa Daniela, Attanasio Vittorio, Sbrana Francesco, Corcione Antonio, Tascini Carlo
First Division of Infectious Diseases, Cotugno Hospital, Azienda Ospedaliera dei Colli, Napoli, Italy.
Intensive Care Unit, Cotugno Hospital, Azienda Ospedaliera dei Colli, Napoli, Italy.
New Microbiol. 2017 Jan;40(1):72-74.
Most clinicians in developed countries have limited experience in making clinical assessments of malaria disease severity and/or monitoring high-level parasitemia in febrile patients with imported malaria. Hyperparasitemia is a risk factor for severe P. falciparum malaria, and procalcitonin (PCT) has recently been related to the severity of malaria. In developed countries, where not all hospital have skilled personnel to count parasitemia, a rapid test might be useful for the prompt diagnosis of malaria but unfortunately these tests are not able to count the number of parasites. In this context, PCT might have a prognostic value for the assessment of severe malaria, especially in children with cerebral malaria. We describe two children with severe cerebral malaria, who were directly admitted to the ICU with a high level of PCT and extremely high (>25%) parasitemia. Our conclusion is that PCT may also be a measure of severity of P. falciparum malaria in children.
在发达国家，大多数临床医生在对疟疾疾病严重程度进行临床评估和/或监测输入性疟疾发热患者的高寄生虫血症方面经验有限。高寄生虫血症是重症恶性疟原虫疟疾的一个危险因素，而降钙素原（PCT）最近与疟疾的严重程度相关。在发达国家，并非所有医院都有技术人员来计数寄生虫血症，快速检测可能有助于疟疾的快速诊断，但不幸的是这些检测无法计数寄生虫数量。在这种情况下，PCT可能对重症疟疾的评估具有预后价值，尤其是对患有脑型疟疾的儿童。我们描述了两名患有严重脑型疟疾的儿童，他们因PCT水平高和寄生虫血症极高（>25%）而直接入住重症监护病房。我们的结论是，PCT也可能是儿童恶性疟原虫疟疾严重程度的一个指标。
