Wang Qiang, Zheng Lan, He Yu-Tao, Liang Yong-Min
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
Chem Commun (Camb). 2017 Mar 2;53(19):2814-2817. doi: 10.1039/c7cc00259a.
The first example of Pd-catalyzed four-component carbonylative difluoroalkylation/perfluoroalkylation through the alkyne difunctionalization process is achieved. The reaction proceeds smoothly under mild conditions in the presence of 1 atm of CO at room temperature with good yields and E-selectivities. The utilization of CsF as an additive is vital to the success of the reaction.
实现了通过炔烃双官能化过程进行钯催化的四组分羰基化二氟烷基化/全氟烷基化的首例反应。该反应在室温、1个大气压CO存在的温和条件下顺利进行，产率良好且具有E选择性。使用CsF作为添加剂对反应的成功至关重要。
