Lydon Helen L, Hall Charlotte A, Dalton Christopher H, Chipman J Kevin, Graham John S, Chilcott Robert P
Centre for Radiation, Chemical and Environmental Hazards, Health Protection Agency, Chilton, UK.
University of Birmingham, Edgbaston, Birmingham, UK.
J Appl Toxicol. 2017 Aug;37(8):976-984. doi: 10.1002/jat.3446. Epub 2017 Feb 20.
Previous studies have demonstrated that haemostatic products with an absorptive mechanism of action retain their clotting efficiency in the presence of toxic materials and are effective in decontaminating chemical warfare (CW) agents when applied to normal, intact skin. The purpose of this in vitro study was to assess three candidate haemostatic products for effectiveness in the decontamination of superficially damaged porcine skin exposed to the radiolabelled CW agents, soman (GD), VX and sulphur mustard (HD). Controlled physical damage (removal of the upper 100 μm skin layer) resulted in a significant enhancement of the dermal absorption of all three CW agents. Of the haemostatic products assessed, WoundStat™ was consistently the most effective, being equivalent in performance to a standard military decontaminant (fuller's earth). These data suggest that judicious application of haemostatic products to wounds contaminated with CW agents may be a viable option for the clinical management of casualties presenting with contaminated, haemorrhaging injuries. Further studies using a relevant animal model are required to confirm the potential clinical efficacy of WoundStat™ for treating wounds contaminated with CW agents. Copyright © 2017 John Wiley & Sons, Ltd.
先前的研究表明，具有吸收作用机制的止血产品在有毒物质存在的情况下仍能保持其凝血效率，并且当应用于正常、完整的皮肤时，对化学战（CW）剂具有去污效果。这项体外研究的目的是评估三种候选止血产品对暴露于放射性标记的CW剂、梭曼（GD）、VX和芥子气（HD）的浅表受损猪皮肤的去污效果。可控的物理损伤（去除上层100μm皮肤层）导致所有三种CW剂的皮肤吸收显著增强。在所评估的止血产品中，WoundStat™始终是最有效的，其性能与标准军事去污剂（漂白土）相当。这些数据表明，将止血产品明智地应用于被CW剂污染的伤口，对于处理出现污染、出血性损伤的伤员的临床管理可能是一个可行的选择。需要使用相关动物模型进行进一步研究，以确认WoundStat™治疗被CW剂污染伤口的潜在临床疗效。版权所有© 2017约翰威立父子有限公司。
