用脂肽抗生素LY146032治疗仓鼠艰难梭菌结肠炎。
Treatment of Clostridium difficile colitis in hamsters with a lipopeptide antibiotic, LY146032.
作者信息
Dong M Y, Chang T W, Gorbach S L
机构信息
Department of Community Health, Tufts University School of Medicine, Boston, Massachusetts 02111.
出版信息
Antimicrob Agents Chemother. 1987 Jul;31(7):1135-6. doi: 10.1128/AAC.31.7.1135.
Abstract
LY146032, an acidic lipopeptide antibiotic which inhibits the biosynthesis of cell wall peptidoglycan, was found to be effective in delaying death in a hamster model of pseudomembranous colitis. A dose of 0.05 mg/day was effective. The equivalent protection with vancomycin required a dose 100-fold higher, i.e., 5 mg/day.
摘要
LY146032是一种酸性脂肽抗生素，可抑制细胞壁肽聚糖的生物合成，在假膜性结肠炎仓鼠模型中被发现能有效延缓死亡。每天0.05毫克的剂量有效。万古霉素达到同等保护效果所需剂量高100倍，即每天5毫克。
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