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用脂肽抗生素LY146032治疗仓鼠艰难梭菌结肠炎。

Treatment of Clostridium difficile colitis in hamsters with a lipopeptide antibiotic, LY146032.

作者信息

Dong M Y, Chang T W, Gorbach S L

机构信息

Department of Community Health, Tufts University School of Medicine, Boston, Massachusetts 02111.

出版信息

Antimicrob Agents Chemother. 1987 Jul;31(7):1135-6. doi: 10.1128/AAC.31.7.1135.

DOI:10.1128/AAC.31.7.1135
PMID:2821892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174884/
Abstract

LY146032, an acidic lipopeptide antibiotic which inhibits the biosynthesis of cell wall peptidoglycan, was found to be effective in delaying death in a hamster model of pseudomembranous colitis. A dose of 0.05 mg/day was effective. The equivalent protection with vancomycin required a dose 100-fold higher, i.e., 5 mg/day.

摘要

LY146032是一种酸性脂肽抗生素，可抑制细胞壁肽聚糖的生物合成，在假膜性结肠炎仓鼠模型中被发现能有效延缓死亡。每天0.05毫克的剂量有效。万古霉素达到同等保护效果所需剂量高100倍，即每天5毫克。

相似文献

1
Treatment of Clostridium difficile colitis in hamsters with a lipopeptide antibiotic, LY146032.用脂肽抗生素LY146032治疗仓鼠艰难梭菌结肠炎。
Antimicrob Agents Chemother. 1987 Jul;31(7):1135-6. doi: 10.1128/AAC.31.7.1135.
2
LY146032 treatment of Clostridium difficile colitis in hamsters.LY146032对仓鼠艰难梭菌结肠炎的治疗
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Effect of bismuth subsalicylate on Clostridium difficile colitis in hamsters.
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本文引用的文献

1
Effect of calcium on in vitro activity of LY146032 against Clostridium difficile.钙对LY146032体外抗艰难梭菌活性的影响。
Antimicrob Agents Chemother. 1987 Mar;31(3):461-2. doi: 10.1128/AAC.31.3.461.
2
Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters.仓鼠中由产毒素梭状芽孢杆菌引起的克林霉素相关性结肠炎。
J Infect Dis. 1977 Nov;136(5):701-5. doi: 10.1093/infdis/136.5.701.
3
The protective effect of vancomycin on clindamycin-induced colitis in hamsters.万古霉素对仓鼠克林霉素诱导的结肠炎的保护作用。
Johns Hopkins Med J. 1977 Oct;141(4):183-92.
4
Neutralization of Clostridium difficile toxin by Clostridium sordellii antitoxins.索氏梭菌抗毒素对艰难梭菌毒素的中和作用。
Infect Immun. 1978 Nov;22(2):418-22. doi: 10.1128/iai.22.2.418-422.1978.