钙对LY146032体外抗艰难梭菌活性的影响。
Effect of calcium on in vitro activity of LY146032 against Clostridium difficile.
作者信息
Faruki H, Niles A C, Heeren R L, Murray P R
出版信息
Antimicrob Agents Chemother. 1987 Mar;31(3):461-2. doi: 10.1128/AAC.31.3.461.
Abstract
The in vitro MICs of LY146032 against 63 isolates of Clostridium difficile tested in Wilkins-Chalgren broth ranged from 0.5 to greater than 32 micrograms/ml, with MICs of 4 and 8 micrograms/ml for 50 and 90% of the isolates, respectively. However, when the test medium was supplemented with physiologic concentrations of calcium, the MIC for 90% of the isolates was reduced to less than or equal to 0.12 microgram/ml.
摘要
在威尔金斯 - 查尔格伦肉汤中对63株艰难梭菌进行测试时，LY146032的体外最低抑菌浓度（MIC）范围为0.5至大于32微克/毫升，50%和90%的分离株的MIC分别为4和8微克/毫升。然而，当测试培养基补充生理浓度的钙时，90%分离株的MIC降至小于或等于0.12微克/毫升。
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