Sulo Enxhela, Nygård Ottar, Vollset Stein Emil, Igland Jannicke, Ebbing Marta, Østbye Truls, Jørgensen Torben, Sulo Gerhard, Tell Grethe S
Department of Global Public Health and Primary Care, University of Bergen, Norway
Department of Clinical Science, University of Bergen, Norway.
J Am Heart Assoc. 2017 Feb 20;6(2):e005236. doi: 10.1161/JAHA.116.005236.
Recent time trends and educational gradients characterizing out-of-hospital coronary deaths (OHCD) are poorly described.
We identified all deaths from coronary heart disease occurring outside the hospital in Norway during 1995 to 2009. Time trends were explored using Poisson regression analysis with year as the independent, continuous variable. Information on the highest achieved education was obtained from The National Education Database and classified as primary (up to 10 years of compulsory education), secondary (high school or vocational school), or tertiary (college/university). Educational gradients in OHCD were explored using Poisson regression, stratified by sex and age (<70 and ≥70 years), and results were expressed as incidence rate ratios (IRRs) and 95%CIs. Of 100 783 coronary heart disease deaths, 58.8% were OHCDs. From 1995 to 2009, age-adjusted OHCD rates declined across all education categories (primary, secondary, and tertiary) in younger men (IRR=0.35; 95%CI 0.32-0.38; IRR=0.38; 95%CI 0.35-0.42; IRR=0.33; 95%CI 0.28-0.40), younger women (IRR=0.47; 95% CI 0.40-0.56; IRR=0.55; 95%CI 0.45-0.67; IRR=0.28; 95% CI 0.16-0.47), older men (IRR=0.20; 95%CI 0.19-0.22; IRR=0.20; 95%CI 0.18-0.22; IRR=0.20; 95%CI 0.17-0.23), and older women (IRR=0.26; 95%CI 0.24-0.28; IRR=0.25; 95%CI 0.23-0.28; IRR=0.28; 95%CI 0.22-0.34). Tertiary education was associated with lower risk of OHCD compared to primary education (IRR=0.37; 95%CI 0.35-0.40 in younger men, IRR=0.26; 95%CI 0.22-0.30 in younger women, IRR=0.52; 95%CI 0.49-0.55 in older men, and IRR=0.61; 95%CI 0.57-0.66 in older women). These gradients did not change over time ( interaction=0.25).
Although OHCD rates declined substantially during 1995 to 2009, they displayed educational gradients that remained constant over time.
关于院外冠心病死亡(OHCD)的近期时间趋势和教育梯度的描述较少。
我们确定了1995年至2009年挪威境内所有院外冠心病死亡病例。使用以年份为独立连续变量的泊松回归分析来探究时间趋势。从国家教育数据库获取最高学历信息,并分为小学(至多10年义务教育)、中学(高中或职业学校)或高等教育(学院/大学)。使用泊松回归按性别和年龄(<70岁和≥70岁)分层探究OHCD中的教育梯度,结果以发病率比(IRR)和95%置信区间表示。在100783例冠心病死亡病例中,58.8%为院外冠心病死亡。从1995年到2009年,年轻男性(IRR = 0.35;95%CI 0.32 - 0.38;IRR = 0.38;95%CI 0.35 - 0.42;IRR = 0.33;95%CI 0.28 - 0.40)、年轻女性(IRR = 0.47;95%CI 0.40 - 0.56;IRR = 0.55;95%CI 0.45 - 0.67;IRR = 0.28;95%CI 0.16 - 0.47)、老年男性(IRR = 0.20;95%CI 0.19 - 0.22;IRR = 0.20;95%CI 0.18 - 0.22;IRR = 0.20;95%CI 0.17 - 0.23)和老年女性(IRR = 0.26;95%CI 0.24 - 0.28;IRR = 0.25;95%CI 0.23 - 0.28;IRR = 0.28;95%CI 0.22 - 0.34)中,所有教育类别(小学、中学和高等教育)的年龄调整后OHCD率均下降。与小学教育相比,高等教育与较低的OHCD风险相关(年轻男性中IRR = 0.37;95%CI 0.35 - 0.40,年轻女性中IRR = 0.26;95%CI 0.22 - 0.30,老年男性中IRR = 0.52;95%CI 0.49 - 0.55,老年女性中IRR = 0.61;95%CI 0.57 - 0.66)。这些梯度未随时间变化(交互作用 = 0.25)。
尽管1995年至2009年期间OHCD率大幅下降,但它们呈现出随时间保持不变的教育梯度。