Katzorke Andrea, Zeller Julia B M, Müller Laura D, Lauer Martin, Polak Thomas, Reif Andreas, Deckert Jürgen, Herrmann Martin J
Department of Psychiatry, Psychosomatics and Psychotherapy, University Clinic Würzburg Würzburg, Germany.
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt Frankfurt am Main, Germany.
Front Hum Neurosci. 2017 Feb 6;11:46. doi: 10.3389/fnhum.2017.00046. eCollection 2017.
Apolipoprotein-E4 (-E4) is a major genetic risk factor for developing Alzheimer's disease (AD). The verbal fluency task (VFT), especially the subtask category fluency, has shown to provide a good discrimination between cognitively normal controls and subjects with AD. Interestingly, -E4 seems to have no effect on the behavioral performance during a VFT in healthy elderly. Thus, the purpose of the present study was to reveal possible compensation mechanisms by investigating the effect of -E4 on the hemodynamic response in non-demented elderly during a VFT by using functional near-infrared spectroscopy (fNIRS). We compared performance and hemodynamic response of high risk -E4/E4, -E3/E4 carriers with neutral -E3/E3 non-demented subjects ( = 288; 70-77 years). No difference in performance was found. -E4/E4, -E3/E4 carriers had a decreased hemodynamic response in the right inferior frontal junction (IFJ) with a corresponding higher response in the left middle frontal gyrus (MFG) during category fluency. Performance was correlated with the hemodynamic response in the MFG. We assume a compensation of decreased IFJ brain activation by utilizing the MFG during category fluency and thus resulting in no behavioral differences between -groups during the performance of a VFT.
载脂蛋白E4（-E4）是患阿尔茨海默病（AD）的主要遗传风险因素。言语流畅性任务（VFT），尤其是子任务类别流畅性，已显示出能很好地区分认知正常对照组和AD患者。有趣的是，-E4似乎对健康老年人在VFT期间的行为表现没有影响。因此，本研究的目的是通过使用功能近红外光谱（fNIRS）研究-E4对非痴呆老年人在VFT期间血液动力学反应的影响，以揭示可能的补偿机制。我们比较了高风险-E4/E4、-E3/E4携带者与中性-E3/E3非痴呆受试者（n = 288；70 - 77岁）的表现和血液动力学反应。未发现表现上的差异。-E4/E4、-E3/E4携带者在类别流畅性任务期间右下额叶交界处（IFJ）的血液动力学反应降低，而左额中回（MFG）的反应相应较高。表现与MFG的血液动力学反应相关。我们假设在类别流畅性任务期间通过利用MFG来补偿IFJ脑激活的降低，从而导致在VFT执行期间各组之间没有行为差异。
