通过酶生物催化将一氧化氮递送至常规流出道的局部和控制释放：治疗青光眼的新途径。
Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma.
机构信息
Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.
Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK.
出版信息
Adv Mater. 2017 Apr;29(16). doi: 10.1002/adma.201604932. Epub 2017 Feb 21.
Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location- and dose-dependent. A NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model.
一氧化氮（NO）能够降低眼内压（IOP）；然而，其对流出生理学的治疗效果取决于位置和剂量。据报道，一种能够直接针对传统流出途径的阻力产生区域并局部释放受控剂量的 NO 的 NO 输送平台。在小鼠模型中，发现流出率（IOP 降低）增加。
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