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用于控释行为的聚合物一氧化氮供体纳米混合涂层中的结构异质性。

Structural heterogeneity in polymeric nitric oxide donor nanoblended coatings for controlled release behaviors.

作者信息

Jeong Hyejoong, Park Kyungtae, Yoo Jae-Chan, Hong Jinkee

机构信息

Department of Chemical and Biomolecular Engineering, Yonsei University Seoul 03722 Republic of Korea

Biotechnology Research Center, JCBIO Co., LTD, Avison Biomedical Research Center (ABMAC), Yonsei University Seoul 03722 Republic of Korea.

出版信息

RSC Adv. 2018 Nov 19;8(68):38792-38800. doi: 10.1039/c8ra07707j. eCollection 2018 Nov 16.

DOI:10.1039/c8ra07707j
PMID:35558288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9090654/
Abstract

Nitric oxide (NO) gas delivery has attracted extensive interest due to its endogenous therapeutic functions and potential biomedical applications for the treatment of various diseases. The important thing about NO delivery is the emission control due to the fast diffusion rate of gas molecules. To develop NO delivery platforms using macromolecules and to comprehend the chemical NO donor generation and release mechanisms, we studied branched polyethyleneimine/alginate (BPEI/ALG) nanoblended coatings fabricated by giving structural heterogeneity to the structure through a self-assembly process for the controlled release of gas molecules. NO release could be remarkably expected the well-organized coating structures and explained by quantification of the NO donors. Taking advantage of these polymeric coatings, this process could be applied to the treatment of various diseases based on the biocompatibility of materials and the fine control of NO release rate and its amount.

摘要

由于一氧化氮（NO）气体具有内源性治疗功能以及在治疗各种疾病方面的潜在生物医学应用，其气体递送已引起广泛关注。关于NO递送的重要之处在于，由于气体分子扩散速率快，需要控制其排放。为了开发使用大分子的NO递送平台并理解化学NO供体的产生和释放机制，我们研究了通过自组装过程赋予结构异质性以实现气体分子可控释放而制备的支化聚乙烯亚胺/藻酸盐（BPEI/ALG）纳米混合涂层。通过对NO供体进行定量，可以明显预期到有序的涂层结构会释放NO。利用这些聚合物涂层，基于材料的生物相容性以及对NO释放速率及其量的精确控制，该过程可应用于各种疾病的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfba/9090654/4d3c3a179974/c8ra07707j-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfba/9090654/99769a157fc1/c8ra07707j-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfba/9090654/b6ff22f193bd/c8ra07707j-f2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfba/9090654/1335ca811499/c8ra07707j-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfba/9090654/4d3c3a179974/c8ra07707j-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfba/9090654/99769a157fc1/c8ra07707j-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfba/9090654/b6ff22f193bd/c8ra07707j-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfba/9090654/dc408ad49cb5/c8ra07707j-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfba/9090654/1335ca811499/c8ra07707j-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfba/9090654/4d3c3a179974/c8ra07707j-f5.jpg

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