1型糖尿病儿童及青少年的非高密度脂蛋白胆固醇与C反应蛋白
Non-HDL-cholesterol and C-reactive protein in children and adolescents with type 1 diabetes.
作者信息
Prado María Mercedes, Carrizo Teresita, Abregú Adela Victoria, Meroño Tomás
出版信息
J Pediatr Endocrinol Metab. 2017 Mar 1;30(3):285-288. doi: 10.1515/jpem-2016-0307.
BACKGROUND
To what extent high sensitivity C-reactive protein (hsCRP) is associated with known cardiovascular risk factors in children with type 1 diabetes (T1D) has not been fully explored.
METHODS
Forty-two T1D children (age: 12+/-1 years) without hypertension, retinopathy, hypothyroidism, albuminuria or other endocrine diseases and 20 controls were studied. Out of the 42 T1D patients studied 57% were prepubertal or early pubertal (Tanner I/II), 38% were pubertal (Tanner III/IV) and 5% post-pubertal (Tanner V).
RESULTS
Children with T1D showed higher hsCRP than controls [0.51 (0.31-1.71 vs. 0.20 (0.20-0.90) mg/L, p<0.05]. However, hsCRP levels were not different in subgroup analysis [hemoglobin A1c (HbA1c)>7.5% or disease duration>3 years] within the group of children with T1D. Conversely, non-high density lipoprotein (HDL)-cholesterol was different in the subgroup analysis. Moreover non-HDL-cholesterol was correlated with age (r=0.37, p<0.01), disease duration (r=0.36, p<0.01) and fasting glucose (r=0.55, p<0.0001).
CONCLUSIONS
Non-HDL-cholesterol might be more useful than hsCRP to evaluate future cardiovascular risk in children with T1D.
背景
1型糖尿病（T1D）患儿中，高敏C反应蛋白（hsCRP）与已知心血管危险因素的关联程度尚未得到充分研究。
方法
对42例无高血压、视网膜病变、甲状腺功能减退、蛋白尿或其他内分泌疾病的T1D患儿（年龄：12±1岁）和20名对照者进行了研究。在研究的42例T1D患者中，57%为青春期前或青春期早期（坦纳I/II期），38%为青春期（坦纳III/IV期），5%为青春期后（坦纳V期）。
结果
T1D患儿的hsCRP高于对照组[0.51（0.31 - 1.71）对0.20（0.20 - 0.90）mg/L，p<0.05]。然而，在T1D患儿组内的亚组分析[糖化血红蛋白（HbA1c）>7.5%或病程>3年]中，hsCRP水平并无差异。相反，亚组分析中低密度脂蛋白胆固醇（HDL）不同。此外，非HDL胆固醇与年龄（r = 0.37，p<0.01）、病程（r = 0.36，p<0.01）和空腹血糖（r = 0.55，p<0.0001）相关。
结论
在评估T1D患儿未来心血管风险方面，非HDL胆固醇可能比hsCRP更有用。
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