Pediatric Diabetes, Endocrine and Metabolism Unit, Children Hospital, Cairo University, Cairo 12664, Egypt.
Laboratory of Diabetes Research, Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz, Universidad Autónoma, 28040 Madrid, Spain.
Int J Mol Sci. 2020 Jul 18;21(14):5079. doi: 10.3390/ijms21145079.
Uncontrolled type-1 diabetes (T1DM) can lead to dyslipidaemia and albuminuria, which may promote cardiovascular injuries. However, some lipidemic factors could be useful in predicting cardiac dysfunction. Seventy-eight adolescents under insulin treatment due to a 6-year history of T1DM and were retrospectively examined. Glycemia, lipidemia, and albuminuria were measured in addition to development of cardiovascular abnormalities Both girls and boys showed higher HbA1c and fasting blood glucose and 27.1% females and 33.3% males exhibited microalbuminuria though their plasma levels of total cholesterol (TC), triglycerides (TG), and low-density lipoproteins (LDL) and high-density lipoproteins (HDL lipoproteins were in the normal range. They exhibited a preserved systolic function, but 50% of females and 66.6% of males had developed diastolic failures. Interestingly, girls with diastolic dysfunction showed significantly lower concentrations of HDL and higher TC/HDL and TG/HDL ratios. In fact, low HDL levels (OR 0.93; 95% CI 0.88-0.99; = 0.029) and high TC/HDL (OR 2.55; 95% CI 1.9-5.45; = 0.016) and TG/HDL (OR 2.74; 95% CI 1.12-6.71; = 0.028) ratios associated with the development of diastolic complications. The cut-off values for HDL, TC/HDL, and TG/HDL were 49 mg/dL, 3.0 and 1.85, respectively. HDL and TC/HDL and TG/HDL ratios may be useful for predicting diastolic dysfunction in girls with uncontrolled T1DM.
未控制的 1 型糖尿病（T1DM）可导致血脂异常和白蛋白尿，从而促进心血管损伤。然而，一些血脂因素可能有助于预测心脏功能障碍。对 78 名因 6 年 T1DM 病史而接受胰岛素治疗的青少年进行了回顾性检查。除了心血管异常的发展外，还测量了血糖、血脂和白蛋白尿。尽管女孩和男孩的总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白（LDL）以及高密度脂蛋白（HDL）脂蛋白的血浆水平在正常范围内，但他们的 HbA1c 和空腹血糖更高，27.1%的女孩和 33.3%的男孩出现微量白蛋白尿。他们表现出收缩功能正常，但 50%的女孩和 66.6%的男孩出现舒张功能衰竭。有趣的是，舒张功能障碍的女孩 HDL 浓度显著降低，TC/HDL 和 TG/HDL 比值更高。事实上，低 HDL 水平（OR 0.93；95%CI 0.88-0.99； = 0.029）和高 TC/HDL（OR 2.55；95%CI 1.9-5.45； = 0.016）和 TG/HDL（OR 2.74；95%CI 1.12-6.71； = 0.028）比值与舒张并发症的发展相关。HDL、TC/HDL 和 TG/HDL 的截止值分别为 49mg/dL、3.0 和 1.85。HDL 和 TC/HDL 和 TG/HDL 比值可用于预测未控制的 T1DM 女孩的舒张功能障碍。
