Wang Feng, Zhao Hualing, Yang Chao, Kong Guilan, Song Lu, Li Chunhui, Wang Yiming, Chen Shuohua, Wang Jing, Wu Shouling
1 Sixth Hospital of Peking University, Beijing, China.
2 North China University of Science and Technology, Tangshan, China.
J Int Med Res. 2017 Feb;45(1):123-133. doi: 10.1177/0300060516677175. Epub 2016 Dec 22.
Objective Toexplore the correlation between blood pressure in the supine position and target organ damage in subjects over 60 years of age. Methods In 2444 individuals, we investigated the association of systolic blood pressure (SBP) in the supine position with the target organ damage indices microalbuminuria (ALBU), brachial-ankle pulse wave velocity (baPWV), and carotid intima-media thickness (IMT). Supine hypertension (SH) is defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg. Subjects were assigned to either the SH group (1275 cases) or the non-SH group (1169 cases). Results The levels of ALBU, baPWV, and IMT, as well as the percentage of participants with ALBU > 30 mg/L, baPWV ≥ 1400 cm/s, and IMT ≥ 1 mm, were significantly higher in the SH group than in the non-SH group. Multivariate logistic regression analysis showed that SH was an independent risk factor for baPWV and IMT, but the relationship with ALBU was not statistically significant after correction for confounding factors. Conclusions SH is a risk factor for target organ damage, as expressed by the indices baPWV and IMT. The association of SH with kidney damage requires further study.
目的 探讨60岁以上人群仰卧位血压与靶器官损害之间的相关性。方法 在2444例个体中，我们研究了仰卧位收缩压（SBP）与靶器官损害指标微量白蛋白尿（ALBU）、臂踝脉搏波速度（baPWV）和颈动脉内膜中层厚度（IMT）之间的关联。仰卧位高血压（SH）定义为收缩压≥140 mmHg和/或舒张压≥90 mmHg。将受试者分为SH组（1275例）和非SH组（1169例）。结果 SH组的ALBU、baPWV和IMT水平，以及ALBU>30 mg/L、baPWV≥1400 cm/s和IMT≥1 mm的参与者百分比均显著高于非SH组。多因素逻辑回归分析显示，SH是baPWV和IMT的独立危险因素，但校正混杂因素后与ALBU的关系无统计学意义。结论 以baPWV和IMT指标表示，SH是靶器官损害的危险因素。SH与肾脏损害的关联需要进一步研究。
