Chatterjee Devoshree, Iliffe Steve, Kharicha Kalpa, Harari Danielle, Swift Cameron, Gillman Gerhard, Stuck Andreas E
University College London,London,UK.
Prim Health Care Res Dev. 2017 May;18(3):253-260. doi: 10.1017/S1463423617000068. Epub 2017 Feb 22.
Aim To investigate whether the use of long-acting benzodiazepines, in individuals aged 65 and over is mediated by physical or psychological factors.
Long-acting benzodiazepine consumption among older people has implications for mortality, morbidity and cost-effective prescribing. Two models explain benzodiazepine use in this age group, one linked to physical illness and disability and one to psychological factors.
Secondary analysis of baseline data from a study of 1059 community-dwelling non-disabled people aged 65 years and over recruited from three general practices in London. For this analysis, use of long-acting benzodiazepines was defined as any self-reported use of diazepam or nitrazepam in the last four weeks. Associations between demographic factors, health service use, and physical and psychological characteristics and benzodiazepine use were investigated. Findings The prevalence of benzodiazepine use in this sample was 3.3% (35/1059). In univariate analyses, benzodiazepine use was associated with female gender, low income, high consultation rates, physical factors (medication for arthritis or joint pain, polypharmacy, difficulties in instrumental activities of daily living, recent pain) and psychological factors (poor self-perceived health, social isolation, and symptoms of anxiety or agitation). In a multivariate logistic regression analysis only two factors retained statistically significant independent associations with benzodiazepine use: receiving only the state pension (OR=4.0, 95% CI: 1.70, 9.80) and pain in the past four weeks (OR=3.79, 95% CI: 1.36, 10.54).
目的 调查65岁及以上人群使用长效苯二氮䓬类药物是否由身体或心理因素介导。
老年人使用长效苯二氮䓬类药物对死亡率、发病率和经济有效的处方用药有影响。有两种模型解释该年龄组苯二氮䓬类药物的使用情况,一种与身体疾病和残疾有关,另一种与心理因素有关。
对从伦敦的三家全科诊所招募的1059名65岁及以上社区居住的非残疾人群的研究基线数据进行二次分析。对于本分析,长效苯二氮䓬类药物的使用定义为在过去四周内任何自我报告的地西泮或硝西泮使用情况。研究了人口统计学因素、医疗服务使用情况以及身体和心理特征与苯二氮䓬类药物使用之间的关联。结果 该样本中苯二氮䓬类药物的使用率为3.3%(35/1059)。在单变量分析中,苯二氮䓬类药物的使用与女性性别、低收入、高就诊率、身体因素(关节炎或关节疼痛用药、多种药物治疗、日常生活工具性活动困难、近期疼痛)和心理因素(自我感觉健康状况差、社会孤立以及焦虑或激动症状)有关。在多变量逻辑回归分析中,只有两个因素与苯二氮䓬类药物的使用保持统计学上显著的独立关联:仅领取国家养老金(比值比=4.0,95%置信区间:1.70,9.80)和过去四周内疼痛(比值比=3.79,95%置信区间:1.36,10.54)。