Cikanek Shawna J, Carpenter James W, Lindemann Dana M, Hallman R M, Eshar David, Kim In Joong, Almes Kelli M
Departments of Clinical Sciences, Kansas State Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas;, Email:
Departments of Clinical Sciences, Kansas State Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas.
Comp Med. 2017 Feb 1;67(1):51-55.
A 5-y-old, intact, 2.5-kg female domestic rabbit was presented because of blood spatter on the wall of its cage and the toenails of its right hind limb. Physical examination revealed a red, gelatinous mass that spanned the width of the right vertical ear canal. Radiographic images revealed a soft-tissue opacity at the base of the right ear, which was superimposed over the tympanic bulla and extended to the pinna. A CT scan revealed that the soft-tissue mass was within the vertical and horizontal portions of the right external ear canal and extended to the level of the tympanic membrane, with no bony involvement. An incisional biopsy of the mass and subsequent histopathology revealed heterophilic inflammation with bacteria, necrosis, and no evidence of neoplasia. The patient died during anesthesia for removal of the mass at 1 mo after the initial presentation. Necropsy with histopathology of the mass was consistent with Shope fibroma virus in light of the presence of typical intracytoplasmic eosinophilic inclusions. Electron microscopy of paraffin-embedded tissue revealed electron-dense intracytoplasmic structures within neoplastic cells consistent with the diagnosis of Leporipoxvirus. To our knowledge, this report is the first description of Shope fibroma virus invading the external ear canal of a domestic rabbit. Given the results of this case, Shope fibroma should be considered in rabbits presenting with abnormal tissue in the ear canal.
一只5岁、未绝育、体重2.5千克的雌性家兔因笼壁和右后肢脚趾甲上有血迹而前来就诊。体格检查发现一个红色的凝胶状肿物，横跨右垂直耳道的宽度。影像学检查显示右耳根部有软组织密度影，该影重叠于鼓泡之上并延伸至耳廓。CT扫描显示软组织肿物位于右外耳道的垂直和水平部分，并延伸至鼓膜水平，无骨质受累。对肿物进行切开活检及后续组织病理学检查发现有细菌感染引起的嗜异性炎症、坏死，无肿瘤形成的证据。该患兔在初次就诊1个月后因肿物切除麻醉期间死亡。鉴于存在典型的胞浆内嗜酸性包涵体，肿物的尸检及组织病理学检查结果与肖普纤维瘤病毒相符。石蜡包埋组织的电子显微镜检查显示肿瘤细胞内有电子致密的胞浆内结构，符合兔痘病毒的诊断。据我们所知，本报告是对肖普纤维瘤病毒侵袭家兔外耳道的首次描述。根据该病例结果，对于耳道出现异常组织的家兔应考虑肖普纤维瘤。
