Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Vet Ophthalmol. 2022 Sep;25(5):406-411. doi: 10.1111/vop.12986. Epub 2022 Apr 5.
To describe the clinical and histopathologic features as well as response to treatment of a solitary Shope fibroma affecting the eyelid margin of a domestic rabbit.
A seven-year-old female intact domestic rabbit with a progressively enlarging firm, pedunculated, and encrusted inferior eyelid mass of the left eye of 1-month duration.
Under general anesthesia, the crust was removed revealing an ulcerated mass that was excised via a house-shaped resection and submitted for histopathology. Purulent discharge associated with the mass was swabbed for aerobic and anaerobic bacterial culture and sensitivity testing. Histopathology revealed intraepithelial, cytoplasmic leporipoxviral inclusion bodies consistent with Shope fibroma virus. There was no growth on aerobic or anaerobic bacterial culture. The lesion was completely excised, and no recurrence was noted during a 3-month follow-up period.
The solitary nature and clinical appearance of this eyelid margin Shope fibroma are unique. Shope fibroma should be considered a differential diagnosis for eyelid masses in rabbits even in the absence of other cutaneous masses. Thorough systemic evaluation to attempt to distinguish Shope fibroma from malignant myxomatosis should be performed.
描述影响家兔眼睑边缘的孤立性 Shope 纤维瘤的临床和组织病理学特征以及治疗反应。
一只七岁的雌性未绝育家兔，左眼逐渐出现一个月的、逐渐增大的、坚硬的、有蒂的、有鳞屑的下眼睑肿块。
在全身麻醉下，去除鳞屑，露出一个溃疡性肿块，通过屋形切除术切除，并进行组织病理学检查。与肿块相关的脓性分泌物被擦拭进行需氧和厌氧细菌培养和药敏试验。组织病理学显示上皮内、细胞质中有兔痘病毒包涵体，符合 Shope 纤维瘤病毒。需氧和厌氧细菌培养均无生长。病变完全切除，在 3 个月的随访期间无复发。
这种眼睑边缘 Shope 纤维瘤的孤立性和临床表现是独特的。即使没有其他皮肤肿块，Shope 纤维瘤也应被视为兔眼睑肿块的鉴别诊断。应进行彻底的全身评估，以尝试将 Shope 纤维瘤与恶性黏液瘤区分开来。
