[双硫仑对大鼠肝脏醛还原酶的抑制作用]
[Disulfiram inhibition of aldehyde reductase from the rat liver].
作者信息
Pozniakova T N, Konoplitskaia K L, Zakashun T E, Khustochka L N
出版信息
Ukr Biokhim Zh (1978). 1987 May-Jun;59(3):19-23.
PMID:3603729
Abstract
Disulphiram (tetraethylthiuram disulphide teturam, antabus), the known antialcoholic preparation, is studied for its effect on the aldehyde reductase activity (EC 1.1.1.1) in the rats' liver. Apparent Km and V are calculated for acetylaldehyde and NADH as well as Ki of disulphiram relative to the substrate and cofactor of the enzyme. The obtained data permit considering disulphiram a high-specific inhibitor of aldehyde reductase in rats' liver.
摘要
双硫仑（四乙基秋兰姆二硫化物，戒酒硫），一种已知的戒酒制剂，被研究其对大鼠肝脏中醛还原酶活性（EC 1.1.1.1）的影响。计算了乙醛和烟酰胺腺嘌呤二核苷酸（NADH）的表观米氏常数（Km）和最大反应速度（V）以及双硫仑相对于该酶底物和辅因子的抑制常数（Ki）。所获得的数据表明双硫仑是大鼠肝脏中醛还原酶的一种高特异性抑制剂。
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