State Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China.
State Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China.
Adv Colloid Interface Sci. 2017 Apr;242:1-16. doi: 10.1016/j.cis.2017.02.005. Epub 2017 Feb 16.
Fluorescent gold nanoclusters (AuNCs) are emerging as novel fluorescent materials and have attracted more and more attention in the field of biolabeling, biosensing, bioimaging and targeted cancer treatment because of their unusual physicochemical properties, such as long fluorescence lifetime, ultrasmall size, large Stokes shift, strong photoluminescence, as well as excellent biocompatibility and photostability. Recently, significant efforts have been committed to the preparation, functionalization and biomedical application studies of fluorescent AuNCs. In this review, we have summarized the strategies for preparation and surface functionalization of fluorescent AuNCs in the past several years, and highlighted recent advances in the biomedical applications of the relevant fluorescent AuNCs. Based on these observations, we also give a discussion on the current problems and future developments of the fluorescent AuNCs for biomedical applications.
荧光金纳米簇（AuNCs）作为新型荧光材料，由于其独特的物理化学性质，如长荧光寿命、超小尺寸、大斯托克斯位移、强光致发光以及优异的生物相容性和光稳定性，在生物标记、生物传感、生物成像和靶向癌症治疗等领域引起了越来越多的关注。近年来，人们致力于荧光 AuNCs 的制备、功能化及生物医学应用研究。本综述总结了过去几年中荧光 AuNCs 的制备和表面功能化策略，并重点介绍了相关荧光 AuNCs 在生物医学应用方面的最新进展。基于这些观察结果，我们还讨论了荧光 AuNCs 在生物医学应用中目前存在的问题和未来的发展方向。
