Lu Rong, Zhang Yong-Guo, Sun Jun
Division of Gastroenterology and Hepatology, Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Division of Gastroenterology and Hepatology, Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Mol Cell Endocrinol. 2017 Aug 15;451:80-87. doi: 10.1016/j.mce.2017.02.023. Epub 2017 Feb 20.
The Janus kinase/signal transducers and activators for transcription (JAK/STAT) pathway plays crucial roles in regulating apoptosis, proliferation, differentiation, and the inflammatory response. The JAK/STAT families are composed of four JAK family members and seven STAT family members. STAT3 plays a key role in inducing and maintaining a pro-carcinogenic inflammatory microenvironment. Recent evidence suggests that STAT3 regulates diverse biological functions in pathogenesis of diseases, such as infection and cancer. In the current review, we will summarize the research progress of STAT3 activation in infection and cancers. We highlight our recent study on the novel role of STAT3 in Salmonella infection-associated colon cancer. Infection with bacterial AvrA-expressing Salmonella activates the STAT3 pathway, which induces the β-catenin signals and enhances colonic tumorigenesis. STAT3 may be a promising target in developing prevention and treatment for infectious diseases and infection-associated cancers.
Janus激酶/信号转导子和转录激活子（JAK/STAT）通路在调节细胞凋亡、增殖、分化及炎症反应中发挥着关键作用。JAK/STAT家族由四个JAK家族成员和七个STAT家族成员组成。STAT3在诱导和维持促癌炎症微环境中起关键作用。最近的证据表明，STAT3在疾病发病机制（如感染和癌症）中调节多种生物学功能。在本综述中，我们将总结STAT3在感染和癌症中激活的研究进展。我们重点介绍了我们最近关于STAT3在沙门氏菌感染相关结肠癌中的新作用的研究。感染表达细菌AvrA的沙门氏菌会激活STAT3通路，该通路会诱导β-连环蛋白信号并增强结肠肿瘤发生。STAT3可能是开发传染病和感染相关癌症预防和治疗方法的一个有前景的靶点。
