Choi Jee Woong, Kim Bo Ri, Seo Eunmi, Youn Sang Woong
Department of Dermatology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Ann Dermatol. 2017 Feb;29(1):48-54. doi: 10.5021/ad.2017.29.1.48. Epub 2017 Feb 3.
The prevalence and clinical characteristics of psoriatic arthritis (PsA) in patients with psoriasis are not well described in Asian populations, including Koreans.
The purpose of this study was to investigate the prevalence of PsA by using the classification of psoriatic arthritis (CASPAR) criteria on the basis of physical examination only, as well as its correlation with psoriasis severity and other medical conditions including nail psoriasis.
A single-center, cross-sectional observational cohort study was conducted, and the included patients were evaluated for PsA according to the CASPAR criteria. The psoriasis area severity index (PASI) and the nail psoriasis severity index (NAPSI) were calculated.
The prevalence of PsA in patients with psoriasis in Korea was 13.5%. When performing logistic regression, hyperlipidemia and localized pustular psoriasis were found to be significant predictors of PsA. The PASI score was significantly higher in PsA patients than in those with psoriasis alone (=0.014). Psoriatic nail involvement was found in 85.5% of the study population, and all PsA patients had nail psoriasis. The mean NAPSI score was higher in patients with PsA; however, the difference was not statistically significant.
There was a close relation between psoriasis severity and PsA, although nail psoriasis severity was not related to PsA status. Dermatologists can diagnose PsA from current physical findings by using the CASPAR criteria. To validate the CASPAR criteria for PsA diagnosis, the definition of nail psoriasis clinical types and severity in the CASPAR criteria should be reviewed again.
银屑病关节炎(PsA)在银屑病患者中的患病率和临床特征在包括韩国人在内的亚洲人群中尚无充分描述。
本研究旨在仅基于体格检查,采用银屑病关节炎分类标准(CASPAR)来调查PsA的患病率,以及其与银屑病严重程度和包括甲银屑病在内的其他疾病状况的相关性。
进行了一项单中心横断面观察性队列研究,根据CASPAR标准对纳入的患者进行PsA评估。计算银屑病面积严重程度指数(PASI)和甲银屑病严重程度指数(NAPSI)。
韩国银屑病患者中PsA的患病率为13.5%。进行逻辑回归分析时,发现高脂血症和局限性脓疱型银屑病是PsA的显著预测因素。PsA患者的PASI评分显著高于单纯银屑病患者(P = 0.014)。在研究人群中,85.5%的患者有银屑病甲受累,所有PsA患者均有甲银屑病。PsA患者的平均NAPSI评分较高;然而,差异无统计学意义。
银屑病严重程度与PsA之间存在密切关系,尽管甲银屑病严重程度与PsA状态无关。皮肤科医生可通过使用CASPAR标准从当前体格检查结果中诊断PsA。为验证CASPAR标准用于PsA诊断的有效性,应再次审查CASPAR标准中甲银屑病临床类型和严重程度的定义。