CVderm - German Center for Health Services Research in Dermatology, Institute for Health Services Research in Dermatology and Nursing, University Clinics of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany.
Br J Dermatol. 2010 Sep;163(3):580-5. doi: 10.1111/j.1365-2133.2010.09831.x. Epub 2010 Apr 28.
Although nail psoriasis affects a marked proportion of patients with psoriasis and causes significant psychological stress, only few epidemiological data characterizing patients with nail involvement are available.
To gain robust data on the epidemiology and disease burden of nail psoriasis in Germany.
Two nationwide, noninterventional, cross-sectional studies on psoriasis health care were conducted in 2005 and 2007, involving 48 (2005) and 130 (2007) German office-based and clinic-based dermatological centres. Data of n=3531 patients with psoriasis were collected using standardized questionnaires and physical examinations by trained dermatologists. Patients with nail psoriasis were compared with patients without any nail involvement concerning sex, age, disease duration, family history, disease severity, presence of psoriatic arthritis (PsA), health-related quality of life (HRQoL), number of inpatient therapies, and days off work.
Nail psoriasis was diagnosed in 40·9% of the patients; prevalence was 11·2 percentage points higher in men than in women. Patients with nail involvement had a longer disease duration (21·9 vs. 18·1 years), higher disease severity (mean Psoriasis Area and Severity Index 12·7 vs. 9·3), higher frequency of PsA (26·0% vs. 12·7%), stronger impairment of HRQoL (mean Dermatology Life Quality Index 8·9 vs. 7·3), and a 2·5-fold higher rate of inpatient treatments.
Nail involvement is a relevant manifestation of psoriasis and is associated with a higher disease severity and quality of life impairment. Accordingly, management of psoriasis should include a special focus on nail involvement.
尽管指甲银屑病影响了很大一部分银屑病患者，并导致了显著的心理压力，但目前仅有少量描述指甲受累患者的流行病学数据。
获取德国指甲银屑病流行病学和疾病负担的可靠数据。
2005 年和 2007 年进行了两项全国性、非干预性、横断面银屑病医疗保健研究，涉及 48 个（2005 年）和 130 个（2007 年）德国基于诊所和基于办公室的皮肤科中心。通过训练有素的皮肤科医生使用标准化问卷和体格检查收集 n=3531 例银屑病患者的数据。指甲银屑病患者与无任何指甲受累的患者在性别、年龄、疾病持续时间、家族史、疾病严重程度、是否存在银屑病关节炎（PsA）、健康相关生活质量（HRQoL）、住院治疗次数和旷工天数方面进行了比较。
指甲银屑病在 40.9%的患者中被诊断出；男性患病率比女性高 11.2 个百分点。指甲受累的患者疾病持续时间更长（21.9 年 vs. 18.1 年）、疾病严重程度更高（平均银屑病面积和严重程度指数 12.7 vs. 9.3）、银屑病关节炎（26.0% vs. 12.7%）发生频率更高、HRQoL 受损更严重（平均皮肤病生活质量指数 8.9 vs. 7.3），住院治疗的比例也高出 2.5 倍。
指甲受累是银屑病的一种重要表现，与疾病严重程度和生活质量受损有关。因此，银屑病的治疗应特别关注指甲受累。
