Hohlefeld F U, Ewald A, Ehlen F, Tiedt H O, Horn A, Kühn A A, Curio G, Klostermann F, Nikulin V V
Neurophysics Group, Department of Neurology, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Clin Neurophysiol. 2017 Apr;128(4):538-548. doi: 10.1016/j.clinph.2016.12.026. Epub 2017 Jan 17.
Neural interactions between cortex and basal ganglia are pivotal for sensorimotor processing. Specifically, coherency between cortex and subthalamic structures is a frequently studied phenomenon in patients with Parkinson's disease. However, it is unknown whether cortico-subthalamic coherency might also relate to cognitive aspects of task performance, e.g., language processing. Furthermore, standard coherency studies are challenged by how to efficiently handle multi-channel recordings.
In eight patients with Parkinson's disease treated with deep brain stimulation, simultaneous recordings of surface electroencephalography and deep local field potentials were obtained from bilateral subthalamic nuclei, during performing a lexical decision task. A recent multivariate coherency measure (maximized imaginary part of coherency, MIC) was applied, simultaneously accounting for multi-channel recordings.
Cortico-subthalamic synchronization (MIC) in 14-35Hz oscillations positively correlated with accuracy in lexical decisions across patients, but not in 7-13Hz oscillations. In contrast to multivariate MIC, no significant correlation was obtained when extracting cortico-subthalamic synchronization by "standard" bivariate coherency.
Cortico-subthalamic synchronization may relate to non-motor aspects of task performance, here reflected in lexical accuracy.
The results tentatively suggest the relevance of cortico-subthalamic interactions for lexical decisions. Multivariate coherency might be effective to extract neural synchronization from multi-channel recordings.
皮层与基底神经节之间的神经相互作用对感觉运动处理至关重要。具体而言，皮层与丘脑底核结构之间的相干性是帕金森病患者中经常研究的现象。然而，尚不清楚皮层-丘脑底核相干性是否也可能与任务表现的认知方面有关，例如语言处理。此外，标准的相干性研究面临着如何有效处理多通道记录的挑战。
在8例接受深部脑刺激治疗的帕金森病患者中，在执行词汇判断任务期间，从双侧丘脑底核同时记录头皮脑电图和深部局部场电位。应用了一种最新的多变量相干性测量方法（相干性的最大虚部，MIC），同时考虑了多通道记录。
14-35Hz振荡中的皮层-丘脑底核同步（MIC）与患者词汇判断的准确性呈正相关，但在7-13Hz振荡中则不然。与多变量MIC不同，当通过“标准”双变量相干性提取皮层-丘脑底核同步时，未获得显著相关性。
皮层-丘脑底核同步可能与任务表现的非运动方面有关，在此表现为词汇准确性。
结果初步表明皮层-丘脑底核相互作用与词汇判断的相关性。多变量相干性可能有效地从多通道记录中提取神经同步。
