Balci Didem Didar, Celik Ebru, Genc Sebahat, Çelik Muhammet Murat, Inan Mehmet Ugur
Department of Dermatology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
Dermatology. 2016;232(6):664-667. doi: 10.1159/000456032. Epub 2017 Feb 23.
Psoriasis is associated with chronic obstructive pulmonary disease. There is no study on the spirometric pulmonary function testing in patients with psoriasis.
The aim of this study was to compare the spirometric parameters in patients with psoriasis and controls.
Ninety-six patients with psoriasis and 60 sex- and age-matched control subjects were included in this study. Spirometric pulmonary function testing, including percent forced vital capacity (FVC%), percent forced expiratory volume in the 1st second (FEV1%), forced expiratory flow at 25-75% of FVC (FEF25-75%), and FEV1/FVC ratio, was performed in all study subjects.
The mean FEV1/FVC ratio and FEF25-75% were significantly lower in the psoriasis patients than in the controls (82.4 ± 6.3 vs. 90.7 ± 10.7, p < 0.001, and 86.7 ± 24.2 vs. 94.8 ± 23.0, p = 0.04, respectively). Both FEV1/FVC ratio and FEF25-75% were significantly associated with the presence of psoriasis (p < 0.001 and p = 0.029, respectively).
Psoriasis patients had lower mean FEV1/FVC ratios and FEF25-75%, compared with the control subjects. FEV1/FVC and FEF25-75% are independently associated with the presence of psoriasis.
银屑病与慢性阻塞性肺疾病相关。目前尚无关于银屑病患者肺功能肺活量测定的研究。
本研究旨在比较银屑病患者与对照组的肺活量测定参数。
本研究纳入了96例银屑病患者和60例性别及年龄匹配的对照者。对所有研究对象进行了肺功能肺活量测定，包括用力肺活量百分比（FVC%）、第1秒用力呼气量百分比（FEV1%）、FVC的25%-75%时的用力呼气流量（FEF25-75%）以及FEV1/FVC比值。
银屑病患者的平均FEV1/FVC比值和FEF25-75%显著低于对照组（分别为82.4±6.3与90.7±10.7，p<0.001；以及86.7±24.2与94.8±23.0，p=0.04）。FEV1/FVC比值和FEF25-75%均与银屑病的存在显著相关（分别为p<0.001和p=0.029）。
与对照者相比，银屑病患者的平均FEV1/FVC比值和FEF25-75%较低。FEV1/FVC和FEF25-75%与银屑病的存在独立相关。
