Kawamoto Hironori, Hara Hiromichi, Minagawa Shunsuke, Numata Takanori, Araya Jun, Kaneko Yumi, Umezawa Yoshinori, Asahina Akihiko, Nakagawa Hidemi, Kuwano Kazuyoshi
Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.
Mayo Clin Proc Innov Qual Outcomes. 2018 Sep 20;2(4):370-377. doi: 10.1016/j.mayocpiqo.2018.07.006. eCollection 2018 Dec.
To investigate the relationship between psoriasis and interstitial pneumonia (IP).
We analyzed the clinical data of patients with psoriasis treated with biologic agents from June 1, 2008, to June 30, 2017, retrospectively. Chest computed tomography was performed in 392 patients before treatment. The clinical characteristics and radiographic findings of these patients were evaluated.
Of the 392 patients with psoriasis, IP was detected in 8 patients (2%). Bilateral ground-glass and/or irregular linear (reticular) opacity in the lower lung zone was the most common chest computed tomography finding. Five of the 8 patients with IP were treated with anti-interleukin (IL) 12/IL-23 or IL-17 antibodies, leading to decreased or stable IP activity.
Interstitial pneumonia was detected in 2% of patients with psoriasis who needed systemic treatments. Ground-glass and/or irregular linear (reticular) opacity in the bilateral lower lobes was characteristic of IP with psoriasis. The IL-23/IL-17 axis may play important roles in the pathogenesis of IP in psoriasis.
探讨银屑病与间质性肺炎（IP）之间的关系。
我们回顾性分析了2008年6月1日至2017年6月30日接受生物制剂治疗的银屑病患者的临床资料。对392例患者在治疗前进行了胸部计算机断层扫描。评估了这些患者的临床特征和影像学表现。
在392例银屑病患者中，8例（2%）检测出患有间质性肺炎。下肺区双侧磨玻璃样和/或不规则线状（网状）模糊影是最常见的胸部计算机断层扫描表现。8例间质性肺炎患者中有5例接受了抗白细胞介素（IL）-12/IL-23或IL-17抗体治疗，导致间质性肺炎活动度降低或稳定。
在需要全身治疗的银屑病患者中，2%检测出患有间质性肺炎。双侧下叶磨玻璃样和/或不规则线状（网状）模糊影是银屑病合并间质性肺炎的特征。IL-23/IL-17轴可能在银屑病合并间质性肺炎的发病机制中起重要作用。
