Shakeel Eram, Arora Deepika, Jamal Qazi Mohammad Sajid, Akhtar Salman, Khan Mohd Kalim Ahmad, Kamal Mohammad A, Siddiqui Mohd Haris, Lohani Mohtashim, Arif Jamal M
Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University Lucknow, Uttar Pradesh, India.
Department of Bioengineering, Faculty of Engineering, Integral University Lucknow, Uttar Pradesh, India.
Curr Drug Metab. 2018;19(6):523-543. doi: 10.2174/1389200218666170221105402.
Malignant tumors are the leading cause of death in humans. Due to the tedious efforts and investigations made in the field of marine drug discovery, there is now a scientific bridge between marine and pharmaceutical sciences. However, currently only few marine drugs have been lined towards anticancer direction yet many more to are be established in future as well.
This review gives an overview of present status of marine natural products MNPs both at the level of research and clinical stages. The authors haved summarized the detail information of diverse marine organisms that were reportedto be active or potentially active in cancer treatment in the last two decades. Interstingly, marine organisms are abundant producer of plenty of structurally incomparable bioactive metabolites that have unusual mode of actions and diverse biosynthetic pathways.
This review summarizes the associated anticancer properties of different classes of marine natural compounds based on their structural diversity, biological activity, and the molecular mechanisms of action. Emphasis has also be given to recent advances in clinical development of marine agents used in clinical trials.
The present review is summarising the various sources of marine chemicals and their exploration of anticancerous potential. There is justified hope for the discovery and development of new anticancer agents from the marine environment.
恶性肿瘤是人类死亡的主要原因。由于在海洋药物发现领域付出了艰辛努力并进行了大量研究，如今海洋科学与制药科学之间已搭建起科学桥梁。然而，目前仅有少数海洋药物朝着抗癌方向发展，未来还有更多有待开发。
本综述概述了海洋天然产物在研究和临床阶段的现状。作者总结了过去二十年中报道的在癌症治疗中具有活性或潜在活性的各种海洋生物的详细信息。有趣的是，海洋生物是大量结构独特的生物活性代谢物的丰富生产者，这些代谢物具有不同寻常的作用方式和多样的生物合成途径。
本综述基于不同类别的海洋天然化合物的结构多样性、生物活性和分子作用机制，总结了其相关抗癌特性。同时也强调了用于临床试验的海洋药物在临床开发方面的最新进展。
本综述总结了海洋化学物质的各种来源及其抗癌潜力的探索。从海洋环境中发现和开发新的抗癌药物是有充分理由的。
