海洋来源抗癌肽的治疗特性和生物益处。
Therapeutic Properties and Biological Benefits of Marine-Derived Anticancer Peptides.
机构信息
Department of Biomedical Science, Chosun University, Gwangju 501-759, Korea.
Department of Bioinformatics, Kongju National University, Kongju 314-701, Korea.
出版信息
Int J Mol Sci. 2018 Mar 20;19(3):919. doi: 10.3390/ijms19030919.
Various organisms exist in the oceanic environment. These marine organisms provide an abundant source of potential medicines. Many marine peptides possess anticancer properties, some of which have been evaluated for treatment of human cancer in clinical trials. Marine anticancer peptides kill cancer cells through different mechanisms, such as apoptosis, disruption of the tubulin-microtubule balance, and inhibition of angiogenesis. Traditional chemotherapeutic agents have side effects and depress immune responses. Thus, the research and development of novel anticancer peptides with low toxicity to normal human cells and mechanisms of action capable of avoiding multi-drug resistance may provide a new method for anticancer treatment. This review provides useful information on the potential of marine anticancer peptides for human therapy.
海洋环境中存在着各种生物。这些海洋生物为潜在的药物提供了丰富的来源。许多海洋肽具有抗癌特性，其中一些已经在临床试验中被评估用于治疗人类癌症。海洋抗癌肽通过不同的机制杀死癌细胞，如细胞凋亡、微管平衡的破坏和血管生成的抑制。传统的化疗药物有副作用，并抑制免疫反应。因此，研究和开发对正常人类细胞毒性低、作用机制能够避免多药耐药的新型抗癌肽可能为癌症治疗提供新方法。本综述提供了有关海洋抗癌肽对人类治疗潜力的有用信息。
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