脆弱的吞噬细胞：FMRP正向调节吞噬活性。
Fragile phagocytes: FMRP positively regulates engulfment activity.
作者信息
Logan Mary A
机构信息
Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health and Science University, Portland, OR 97239
出版信息
J Cell Biol. 2017 Mar 6;216(3):531-533. doi: 10.1083/jcb.201702034. Epub 2017 Feb 22.
Defective immune system function is implicated in autism spectrum disorders, including Fragile X syndrome. In this issue, O'Connor et al. (2017. https://doi.org/10.1083/jcb.201607093) demonstrate that phagocytic activity of systemic immune cells is compromised in a model of Fragile X, highlighting intriguing new mechanistic connections between FMRP, innate immunity, and abnormal development.
免疫系统功能缺陷与自闭症谱系障碍有关，包括脆性X综合征。在本期杂志中，奥康纳等人（2017年。https://doi.org/10.1083/jcb.201607093）证明，在脆性X模型中，全身免疫细胞的吞噬活性受损，这突出了脆性X智力低下蛋白（FMRP）、先天免疫和异常发育之间有趣的新机制联系。
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