Ferreira da Silva Renato Cesar, Lieberman Scott M, Hoffman Henry T, Policeni Bruno, Bashir Amani, Smith Richard J H, Sato T Shawn
Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA.
Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA.
Radiol Case Rep. 2016 Dec 7;12(1):196-199. doi: 10.1016/j.radcr.2016.10.008. eCollection 2017 Mar.
Immunoglobulin G4-related disease (IgG4RD) is an immune-mediated condition characterized by lymphoplasmacytic infiltrates and fibrosis of affected organs. IgG4RD may affect many different organs either individually or together in a multiorgan condition and, thus, incorporates a wide range of fibroinflammatory phenotypes with shared pathologic features. Although IgG4RD most commonly occurs in late adulthood, it may affect children and adolescents. Only one case of IgG4RD presenting as isolated submandibular gland involvement has been reported in the pediatric population. Radiographic features of IgG4RD are often nonspecific making diagnosis challenging, but it is important for radiologists to be familiar with this diseased as its inclusion the differential for diffuse salivary enlargement may be the first step in making an accurate diagnosis. Here, we report a case of a child presenting with bilateral submandibular gland swelling to increase awareness of this condition in the pediatric population. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
免疫球蛋白G4相关疾病（IgG4RD）是一种免疫介导的疾病，其特征为受累器官出现淋巴细胞和浆细胞浸润以及纤维化。IgG4RD可单独或在多器官病变中共同影响许多不同器官，因此包含了具有共同病理特征的广泛纤维炎症表型。虽然IgG4RD最常见于成年晚期，但也可能影响儿童和青少年。儿科人群中仅报告过1例表现为孤立性下颌下腺受累的IgG4RD病例。IgG4RD的影像学特征通常不具有特异性，这使得诊断具有挑战性，但放射科医生熟悉这种疾病很重要，因为将其纳入弥漫性唾液腺肿大的鉴别诊断中可能是做出准确诊断的第一步。在此，我们报告1例出现双侧下颌下腺肿胀的儿童病例，以提高儿科人群对这种疾病的认识。本研究未获得公共、商业或非营利部门的任何特定资助机构的资助。
