Chan Jeffrey Cy, Burugapalli Krishna, Huang Yi-Shiang, Kelly John L, Pandit Abhay
Department of Plastic, Reconstructive and Hand Surgery, University Hospital Galway, Galway, Ireland; CÚRAM-Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.
Biomedical Engineering Theme, Institute of Environment, Health and Societies, Brunel University London, Uxbridge, UK.
J Tissue Eng. 2016 Dec 30;8:2041731416686532. doi: 10.1177/2041731416686532. eCollection 2017 Jan-Dec.
An animal model that allows for assessment of the degree of stretching or contraction of the implant area and the in vivo degradation properties of biological meshes is required to evaluate their performance in vivo. Adult New Zealand rabbits underwent full thickness subtotal unilateral rectus abdominis muscle excision and were reconstructed with the non-biodegradable Peri-Guard, Prolene or biodegradable Surgisis meshes. Following 8 weeks of recovery, the anterior abdominal wall tissue samples were collected for measurement of the implant dimensions. The Peri-Guard and Prolene meshes showed a slight and obvious shrinkage, respectively, whereas the Surgisis mesh showed stretching, resulting in hernia formation. Surgisis meshes showed in vivo biodegradation and increased collagen formation. This surgical rabbit model for abdominal wall defects is advantageous for evaluating the in vivo behaviour of surgical meshes. Implant area stretching and shrinkage were detected corresponding to mesh properties, and histological analysis and stereological methods supported these findings.
为了评估生物补片在体内的性能，需要一种能够评估植入区域拉伸或收缩程度以及生物补片体内降解特性的动物模型。成年新西兰兔接受单侧腹直肌全层大部切除，并用不可降解的Peri-Guard、普理灵补片或可降解的Surgisis补片进行重建。恢复8周后，收集前腹壁组织样本以测量植入物尺寸。Peri-Guard补片和普理灵补片分别显示出轻微和明显的收缩，而Surgisis补片显示出拉伸，导致疝形成。Surgisis补片显示出体内生物降解并增加了胶原蛋白形成。这种用于腹壁缺损的手术兔模型有利于评估手术补片的体内行为。检测到与补片特性相对应的植入区域拉伸和收缩，组织学分析和体视学方法支持了这些发现。
