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受限的CD4+ T细胞受体库通过改变Th2细胞因子水平损害认知功能。

Restricted CD4+ T cell receptor repertoire impairs cognitive function via alteration of Th2 cytokine levels.

作者信息

Song Eun Ji, Jeon Seong Gak, Kim Kyoung Ah, Kim Jin-Il, Moon Minho

机构信息

Department of Biochemistry, College of Medicine, Konyang University , Daejeon, Republic of Korea.

Department of Nursing, College of Nursing, Jeju National University , Jeju-si, Republic of Korea.

出版信息

Neurogenesis (Austin). 2017 Jan 5;4(1):e1256856. doi: 10.1080/23262133.2016.1256856. eCollection 2017.

DOI:10.1080/23262133.2016.1256856
PMID:28229084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5268764/
Abstract

Despite the effects of CD4+ T cell dysfunction on cognitive and behavioral impairment are well established, the effects of Th2 cytokines on the adult hippocampal neurogenesis and cognitive function in restricted CD4+ T cell receptor (TCR) repertoire model have not been fully elucidate. We found that mice with restricted CD4+ repertoire TCR showed decreased adult hippocampal neurogenesis using OT-II mice. Moreover, we demonstrated that OT-II mice showed increased Th2 cytokine levels in peripheral organs and IL-4 levels in brain. Taken together, altered Th2 cytokine levels may impact learning and memory via impaired adult neurogenesis in restricted CD4+ repertoire TCR mice.

摘要

尽管CD4+ T细胞功能障碍对认知和行为损害的影响已得到充分证实，但在受限的CD4+ T细胞受体（TCR）库模型中，Th2细胞因子对成年海马神经发生和认知功能的影响尚未完全阐明。我们发现，使用OT-II小鼠，具有受限CD4+库TCR的小鼠成年海马神经发生减少。此外，我们证明OT-II小鼠外周器官中的Th2细胞因子水平升高，大脑中的IL-4水平升高。综上所述，Th2细胞因子水平的改变可能通过受限CD4+库TCR小鼠的成年神经发生受损影响学习和记忆。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5662/5268764/8a77d601d9bf/kngs-04-01-1256856-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5662/5268764/8a77d601d9bf/kngs-04-01-1256856-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5662/5268764/8a77d601d9bf/kngs-04-01-1256856-g001.jpg

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